Technology Process of 4',5,7-trihydroxy-3-(tricarbonyl[(1'',2'',3'',4''-η)-2''-methoxy-1'',3''-cyclohexadien-5''α-yl]iron(0))flavanone
There total 2 articles about 4',5,7-trihydroxy-3-(tricarbonyl[(1'',2'',3'',4''-η)-2''-methoxy-1'',3''-cyclohexadien-5''α-yl]iron(0))flavanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; chloro-trimethyl-silane; lithium hexamethyldisilazane;
In
tetrahydrofuran;
(N2); addn. of soln. of LiN(SiMe3)2 in THF to suspn. of C15H12O5 in THF at -78°C for 0.5 h, addn. of Me3SiCl; stirring for 0.5 h; removalof solvent, addn. of CH2Cl2; cooling to -78°C; addn. of soln. of LiN(SiMe3)2/THF; stirring for 0.5 h;; addn. of Fe(CO)3(C6H6OMe)PF6; stirring for 2 h; warming to room temp., treatment with HCl in MeOH/H2O at room temp.; addn. of H2O; extn. with ether, drying of combined extracts over MgSO4; concn. under reduced pressure, chromy. on silica gel; elem. anal;
DOI:10.1016/S0022-328X(02)02146-0
- Guidance literature:
-
With
hydrogenchloride; lithium hexamethyldisilazane;
In
tetrahydrofuran;
(N2); addn. of THF soln. of LiN(SiMe3)2 to stirred soln. of 4',5,7-(CH3OCH2O)3C15H9O2 at -109°C; stirring for 1 h; addn. of Fe(CO)3(C6H6OMe)PF6; stirring for 2h; addn. of H2O; extn., drying, concn., chromy., addn. of HCl in MeOH/H2O at room temp.; addn. of water, extn. with ether, drying of combined extracts over MgSO4, concn. under reduced pressure, chromy. on silica gel with mixt. of hexane/ethyl acetate (4:1 to 2:1) as eluent;
DOI:10.1016/S0022-328X(02)02146-0
