5-propoxy-indole

Base Information

• Chemical Name: 5-propoxy-indole
• CAS No.: 147405-80-9
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol file: 147405-80-9.mol

Synonyms:

Chemical Property of 5-propoxy-indole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-propoxy-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-propoxy-indole

There total 8 articles about 5-propoxy-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

indol-5-ol (1953-54-4) + 1-iodo-propane (107-08-4) → 5-propyloxy-1H-indole (147405-80-9)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1021/jm970460b

Reference yield:

5-benzyloxy-1H-indole (1215-59-4) → 5-propyloxy-1H-indole (147405-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NH₄OCOH / 10percent Pd/C / ethanol / Ambient temperature

2: 98 percent / K₂CO₃ / acetone / Heating

With ammonium formate; potassium carbonate; palladium on activated charcoal; In ethanol; acetone;

DOI:10.1021/jm970460b

Reference yield:

1-(toluene-4-sulfonyl)-1H-indol-5-ol → 5-propyloxy-1H-indole (147405-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 80 °C

2: potassium hydroxide / ethanol / Reflux

With potassium carbonate; potassium hydroxide; In ethanol; acetonitrile;

DOI:10.1016/j.jfluchem.2017.02.003

upstream raw materials:

5-propoxy-indole-2-carboxylic acid

indol-5-ol

1-iodo-propane

5-benzyloxy-1H-indole

Refernces

• 1、 Unzue, Andrea,Zhao, Hongtao,Lolli, Graziano,Dong, Jing,Zhu, Jian,Zechner, Melanie,Dolbois, Aymeric,Caflisch, Amedeo,Nevado, Cristina. "The "gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains". . p. 3087 - 3097. Retrieved 2016/05/19.
• 2、 -. "Tryptamine analogues, their synthesis and their use as 5-HT1 -like or 5-HT2 receptor agonists". . . Retrieved 2008/06/13.