1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 2,3-dihydro-6-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-4-methyl-1-( phenylmethyl)-, monohydrochloride

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 2,3-dihydro-6-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-4-methyl-1-( phenylmethyl)-, monohydrochloride
• CAS No.: 106000-74-2
• Molecular Formula: C₂₂H₂₈N₄O₂*ClH
• Molecular Weight: 416.951

Synonyms:

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 2,3-dihydro-6-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-4-methyl-1-( phenylmethyl)-, monohydrochloride

Chemical Property:

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Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 2,3-dihydro-6-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-4-methyl-1-( phenylmethyl)-, monohydrochloride

There total 3 articles about 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 2,3-dihydro-6-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-4-methyl-1-( phenylmethyl)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Benzyl-6-(3-isopropyl-2-phenyl-oxazolidin-5-ylmethoxy)-4-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile → 1-Benzyl-4-methyl-5-cyano-6-(3'-isopropylamino-2'-hydroxypropoxy)-7-azaindoline hydrochloride (106000-74-2)

Guidance literature:

With hydrogenchloride; In toluene; at 50 ℃; Yield given; pH 3.0;

DOI:10.1007/BF00758561

Reference yield:

2-Phenyl-3-isopropyl-5-(hydroxymethyl)-oxazolidine (54126-58-8) → 1-Benzyl-4-methyl-5-cyano-6-(3'-isopropylamino-2'-hydroxypropoxy)-7-azaindoline hydrochloride (106000-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / dibenzo-18-crown-6 / toluene / Heating

2: 1 N aq. HCl / toluene / 50 °C / pH 3.0

With hydrogenchloride; potassium hydroxide; dibenzo-18-crown-6; In toluene;

DOI:10.1007/BF00758561

Reference yield:

1-benzyl-4-methyl-5-cyano-6-chloro-7-azaindoline (96626-25-4) → 1-Benzyl-4-methyl-5-cyano-6-(3'-isopropylamino-2'-hydroxypropoxy)-7-azaindoline hydrochloride (106000-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / dibenzo-18-crown-6 / toluene / Heating

2: 1 N aq. HCl / toluene / 50 °C / pH 3.0

With hydrogenchloride; potassium hydroxide; dibenzo-18-crown-6; In toluene;

DOI:10.1007/BF00758561

upstream raw materials:

2-Phenyl-3-isopropyl-5-(hydroxymethyl)-oxazolidine

1-benzyl-4-methyl-5-cyano-6-chloro-7-azaindoline

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