54126-58-8

Upstream product

• 6452-57-9 1,2-dihydroxy-3-isopropylaminopropane 
• 100-52-7 benzaldehyde 
• 90742-94-2 S-1,2-dihydroxy-3-isopropylaminopropane 

Downstream Products

• 86587-72-6 2-phenyl-3-isopropyl-5-<(tosyloxy)methyl>oxazolidine 
• 4874-40-2 5-methylthiomethyluracil 
• 54127-77-4 1-isopropylamino-3-(3-phenylsulfanyl-pyrazin-2-yloxy)-propan-2-ol 
• 84905-89-5 1-Benzyl-6-(3'-isopropylamino-2'-hydroxypropoxy)-7-cyano-5-azaindoline 
• 85613-37-2 2-<4-<3-(isopropylamino)-2-hydroxypropoxy>phenyl>-4-(2-thienyl)imidazole 
• 111218-83-8 2-(4'-Furoylpiperazyl)-4-(3'-isopropylamino-2'-oxypropoxy)-6,7-dimethoxyquinazoline hydrochloride 
• 106000-77-5 2-(3'-Isopropylamino-2'-hydroxyisopropoxy)-3-cyano-4-<β-(3',4'-dimethoxyphenyl)ethylamino>pyridine dihydrochloride 
• 106000-74-2 1-Benzyl-4-methyl-5-cyano-6-(3'-isopropylamino-2'-hydroxypropoxy)-7-azaindoline hydrochloride 
• 106000-76-4 2-(3'-Isopropylamino-2'-hydroxyisopropoxy)-3-cyano-4-(α-methyl-β-phenylethylamino)pyridine dihydrochloride 
• 84905-85-1 1-Benzyl-6-(3-isopropyl-2-phenyl-oxazolidin-5-ylmethoxy)-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile 
• 103589-68-0 3-(3-Isopropyl-2-phenyl-oxazolidin-5-ylmethoxy)-5,6,7,8-tetrahydro-isoquinoline-4-carbonitrile 
• 111218-76-9 2-Chloro-4-(3'-isopropylamino-2'-oxypropoxy)-6,7-dimethoxyquinazoline 

Relevant academic research and scientific papers

Synthesis and antiarrhythmic activity of new 1-[1-[2-[3-(alkylamino)-2-hydroxypropoxy]phenyl]vinyl]-1H-imidazoles and related compounds

Various 1-[1-[2-[3-(alkylamino)-2-hydroxypropoxy]phenyl]vinyl]-1H-azoles were synthesized and investigated for β-adrenoceptor-blocking and antiarrhythmic activities. Although no compounds showed more potent β-blocking effects than propranolol in the isolated guinea pig right atria, many compounds exhibited significant antiarrhythmic effects against aconitine or ischemic arrhythmia in mice or dogs. 1-[2,5-Dichloro-6-[1-(1H-imidazol-1-yl)ethenyl]phenoxy]-3-[(1-methylethyl) amino]-2-propanol hydrochloride (48) (711389-S) was selected as a candidate for clinical evaluation in man, since its antiarrhythmic effects were superior to those of quinidine, disopyramide, or propranolol. Asymmetric synthesis of (R)-(+)- and (S)-(-)-48 is described, and it is proven that there is no stereospecificity in the antiarrhythmic effect of 48.

β1-Selective adrenoceptor antagonists: Examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class

A series of 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazoles is described. The compounds were investigated in vitro for β-adrenoceptor antagonism, and several examples were found to be selective for the β1-adrenoceptor. The structure-activity relationship exhibited by this series of compounds is discussed. (S)-2-[p-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]phenyl] -4-(2-thienyl)imidazole [(S)-13] was over 100 times more selective than atenolol for the β1-adrenergic receptor and has been selected for in-depth studies.

1-Substituted-amino-3-(4-furo[3,2-c]pyridinyloxy)-2-propanols

This invention provides new compounds of formula I, STR1 wherein R is alkyl of 3 to 7 carbon atoms or cycloalkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms monosubstituted by alkyl of 1 to 4 carbon atoms, α-dialkylpropynyl of 5 to 9 carbon atoms or α-dialkyl-allyl of 5 to 9 carbon atoms, hydroxyalkyl of 2 to 7 carbon atoms or phenoxyalkyl of 8 to 11 carbon atoms, the oxygen atom of the last two radicals being separated by at least two carbon atoms from the nitrogen atom to which R is bound, R1 is I. hydrogen or alkyl of 1 to 4 carbon atoms in the 2,3,6 or 7 position, or Ii. chlorine or bromine, in the 2, 3 or 7 position, Iii. nitro or --NHA wherein A is alkanoyl of 1 to 4 carbon atoms, in the 2, 3 or 7 position, or Iv. fluorine, cyano or COOB, wherein B is alkyl of 1 to 4 carbon atoms, in the 2 or 3 position, and R2 is I. hydrogen or alkyl of 1 to 4 carbon atoms in the 2, 3, 6 or 7 position, Ii. chlorine or bromine, in the 2, 3 or 7 position, or Iii. fluorine in the 2 or 3 position, useful in the treatment of heart diseases.