Carbonic acid (S)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester

Base Information

Chemical Name:Carbonic acid (S)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester
CAS No.:85994-39-4
Molecular Formula:C₂₇H₄₆N₂O₇Si₂
Molecular Weight:566.842
Hs Code.:

Carbonic acid (S)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester

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Chemical Property of Carbonic acid (S)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester

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Technology Process of Carbonic acid (S)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester

There total 8 articles about Carbonic acid (S)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 85960-26-5,85994-38-3,92693-48-6,114716-52-8
(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-(1-hydroxy-ethyl)-azetidin-2-one

: 4457-32-3
4-nitrobenzyl chloroformate

: 85994-39-4
Carbonic acid (S)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester

: 85960-27-6
Carbonic acid (R)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester

Guidance literature:: With dmap;
DOI:10.1016/S0040-4039(00)81369-6

Reference yield:

: 77881-95-9
(4S)-4-(methoxycarbonylmethyl)-azetidine-2-one

: 85994-39-4
Carbonic acid (S)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄, LiCl / 1,2-dimethoxy-ethane

3: 81 percent / 1.) LDA 2.) NH₄Cl / tetrahydrofuran / 0.33 h / -78 °C

4: 98 percent / K-selectride / diethyl ether

5: 7 percent / DMAP

With dmap; sodium tetrahydroborate; potassium tri-sec-butyl-borohydride; ammonium chloride; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether;
DOI:10.1016/S0040-4039(00)81369-6

Reference yield:

: 88649-80-3
(4S)-1-(t-butyldimethylsilyl)-4-(methoxycarbonylmethyl)-azetidine-2-one

: 85994-39-4
Carbonic acid (S)-1-{(2R,3S)-1-(tert-butyl-dimethyl-silanyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: LiAlH₄ / tetrahydrofuran

2: Et₃N

3: 81 percent / 1.) LDA 2.) NH₄Cl / tetrahydrofuran / 0.33 h / -78 °C

4: 98 percent / K-selectride / diethyl ether

5: 7 percent / DMAP

With dmap; lithium aluminium tetrahydride; potassium tri-sec-butyl-borohydride; ammonium chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4039(00)81369-6