Technology Process of 1,3-Cyclohexanedicarboxylic acid, 1-(2-chloroethyl)-, dimethyl ester
There total 4 articles about 1,3-Cyclohexanedicarboxylic acid, 1-(2-chloroethyl)-, dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
dimethyl cyclohexane-1,3-dicarboxylate;
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -67 - -60 ℃;
for 1h;
1-Bromo-2-chloroethane;
In
tetrahydrofuran; hexane;
at -50 - 20 ℃;
for 19.5h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 80 percent / H2 / W 2 Raney nickel / methanol; tetrahydrofuran / 15 h / 100 - 105 °C / 82743.7 Torr
2: 1.) lithium diisopropylamide / 1.) THF, HMPT, -75 deg C, 40 min, 2.) THF, HMPT, -80 deg C to RT, 1.5 h
With
hydrogen; lithium diisopropyl amide;
W 2 Raney nickel;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: chloro-trimethyl-silane / 96 h / 18 - 25 °C / Inert atmosphere
2.1: diisopropylamine; n-butyllithium / hexane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: -78 - 25 °C
With
n-butyllithium; chloro-trimethyl-silane; diisopropylamine;
In
tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hexane;
