3971-31-1

Usage

Uses

Used in Polymer Synthesis:
1,3-Cyclohexanedicarboxylic acid is used as a monomer in the production of various polymers, including polyesters, polyamides, and polyurethanes. Its chemical structure contributes to the formation of strong and durable polymers with a wide range of applications.
Used in Pharmaceutical Production:
1,3-Cyclohexanedicarboxylic acid serves as a building block in the synthesis of various pharmaceuticals. Its unique properties allow it to be incorporated into the molecular structures of drugs, enhancing their efficacy and performance.
Used in Agrochemicals:
In the agrochemical industry, 1,3-cyclohexanedicarboxylic acid is used as a key component in the development of various agrochemical products. Its incorporation into these products can improve their effectiveness and performance in agricultural applications.
Used in Corrosion Inhibition:
1,3-Cyclohexanedicarboxylic acid is utilized as a corrosion inhibitor, protecting metals and alloys from degradation and wear. Its ability to form protective layers on metal surfaces makes it an effective agent in preventing corrosion in various industrial settings.
Used in Surfactant Formulation:
In the formulation of surfactants, 1,3-cyclohexanedicarboxylic acid is used to enhance the properties of these compounds. Its incorporation can improve the surfactant's performance in various applications, such as detergents, emulsifiers, and wetting agents.
Overall, 1,3-Cyclohexanedicarboxylic acid's diverse applications across different industries highlight its importance and value in modern chemical and material science.

InChI:InChI=1/C8H12O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h5-6H,1-4H2,(H,9,10)(H,11,12)

Upstream product

• 21651-12-7 (E)-2,4-pentadienoic acid 
• 79-10-7 acrylic acid 
• 121-91-5 isophthalic acid 
• 1610728-91-0 (S,S)-dibenzyl cyclohexyl 1,3-dicarboxylate 

Downstream Products

• 3385-21-5 1,3-diaminocyclohexane 
• 2305-31-9 cis-cyclohexane-1,3-dicarboxylic acid 
• 2387-23-7 1,3-Dicyclohexylurea 
• 4355-31-1 3-oxabicyclo[3.3.1]nonane-2,4-dione 
• 62638-06-6 dimethyl cyclohexane-1,3-dicarboxylate 
• 1610729-46-8 5,5'-(cyclohexane-1,3-diyl)bis(1,3,4-thiadiazol-2-amine) 
• 1610729-37-7 N-(5-((1S,3S)-3-(5-amino-1,3,4-thiadiazol-2-yl)cyclohexyl)-1,3,4-thiadiazol-2-yl)-2-(pyridin-2-yl)acetamide 
• 1610727-94-0 N-(5-((1S,3S)-3-(5-acetamido-1,3,4-thiadiazol-2-yl)cyclohexyl)-1,3,4-thiadiazol-2-yl)-2-(3-methoxyphenyl)acetamide 
• 1610728-92-1 5,5'-((1S,3S)-cyclohexane-1,3-diyl)bis(1,3,4-thiadiazol-2-amine) 
• 1259279-62-3 N-[(1R,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]-pyridin-3-yl)pyrimidin-4-yl]amino]cyclohexyl]morpholine-4-carboxamide 
• 952616-39-6 (1R,3S)-3-(((benzyloxy)carbonyl)amino)cyclohexanecarboxylic acid 
• 1261225-49-3 [3-(1R,3S)-benzyloxycarbonylaminocyclohexyl]-1-carbamic acid tertbutyl ester 
• 1259278-17-5 tert-butyl N-[(1R,3S)-3-aminocyclohexyl]carbamate 
• 1259279-59-8 tert-butyl N-[(1R,3S)-3-[[5-fluoro-2-[5-fluoro-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl]amino]cyclohexyl]carbamate 

Relevant academic research and scientific papers

Catalytic hydrogenation products of aromatic and aliphatic dicarboxylic acids

Hydrogenation of aromatic dicarboxylic acids gave 100 % selectivity to respective cyclohexane dicarboxylic acid with 5 % Pd/C catalyst. 5 % Ru/C catalyst was observed to give over hydrogenation products at 493 K and at lower temperature (453 K) the selectivity for cyclohexane dicarboxylic acids was increased. Hydrogenation of phthalic acid with Ru-Sn/Al2O3 catalyst was observed to give phthalide instead of 1,2-benzene dimethanol or 2-hydroxy methyl benzoic acid. Ru-Sn/Al2O3 catalyst selectively hydrogenated the carboxylic group of cyclohexane dicarboxylic acids to give cyclohexane dimethanol. Use of proper catalysts and reaction conditions resulted in desired products.

Synthesis of phthalate-free plasticizers by hydrogenation in water using RhNi bimetallic catalyst on aluminated SBA-15

In this study, rhodium-nickel bimetallic nanoparticles loaded on aluminated silica (RhNi/Al-SBA-15) were used as catalysts for the hydrogenation of phthalate in water to produce environmentally acceptable non-phthalate plasticizers. Chemical fluid deposition (CFD) was used to dope metals onto the aluminated silica support, which helped to create a uniform structure of RhNi on Al-SBA-15. The introduction of Ni helped to reduce the use of expensive Rh and increase the number of metal active sites by reducing the bimetallic nanoparticle size. Aluminated SBA-15 not only acted as the support for the RhNi bimetallic catalyst but also enhanced the reaction efficiency by introducing Br?nsted and Lewis acid sites and the absorption of phthalates on the catalyst in water. The physicochemical properties of prepared catalysts were characterized by N2 adsorption-desorption isotherm, X-ray diffraction (XRD), in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), Scanning electron microscopy (SEM), and Transmission electron microscopy (TEM). The catalytic performance of the synthesized catalysts was evaluated with the hydrogenation of dimethyl phthalate (DMP). Despite the low solubility of DMP in water, the hydrogenation using Rh0.5Ni1.5/Al-SBA-15 was carried out with an 84.4% reaction yield (cis-?:?trans- = 97.5?:?2.5) at 80 °C using 1000 psi of H2 after 2 h.

Cis - 1, 3 - cyclohexane dicarboxylic acid preparation method (by machine translation)

The invention discloses a cis - 1, 3 - cyclohexane dicarboxylic acid, its specific steps are as follows: the isophthalic acid, catalyst and solvent is added to the high pressure in the reactor, via the high-pressure hydrogenation, cis-trans mixture obtain

COMPOUNDS AND THEIR METHODS OF USE

Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES AS GLUTAMINASE INHIBITORS FOR TREATING CANCERS THEREOF

Provided are compounds of formula (I), wherein X, Y, Z, W, m, n, o, p, R1, R2 and R6 are defined as in the description. Pharmaceutical compositions and uses as glutaminase inhibitors for treating cancers thereof are also provided.

COMPOUNDS AND THEIR METHODS OF USE

Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided.

METHOD FOR PRODUCING BIS(AMINOMETHYL)CYCLOHEXANES

A method for producing bis(aminomethyl)cyclohexanes includes a nuclear hydrogenation step of producing hydrogenated phthalic acids or phthalic acid derivatives by nuclear hydrogenation of phthalic acids or phthalic acid derivatives of at least one selecte

Stereoselective process for preparing cylcohexyl amine derivatives

A process for preparing (1R,3S)-3-(9-chloro-3-methyl-4-oxo-5H-(isoxazoloquinolin-5-yl))cyclohexanecarboxylic acid and esters thereof, as represented by formulas II and III, wherein R is a lower alkyl groups, and A and B are N or O, provided that when A is N, B is O, or when A is O, B is N: Formula (III) and Formula (II).

STEREOSELECTIVE PROCESS FOR PREPARING CYCLOHEXYL AMINE DERIVATIVES

A process for preparing (1R,3S)-3-(9-chloro-3-methyl-4-oxo-5H-(isoxazoloquinolin-5-yl))cyclohexanecarboxylic acid and esters thereof, as represented by formulas II and III, wherein R is a lower alkyl groups, and A and B are N or O, provided that when A is