isopropyl 6-amino-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4-(3,5-dimethoxyphenyl)-4H-pyran-3-carboxylate

Base Information

• Chemical Name: isopropyl 6-amino-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4-(3,5-dimethoxyphenyl)-4H-pyran-3-carboxylate
• CAS No.: 445384-31-6
• Molecular Formula: C₃₀H₃₂N₄O₅S
• Molecular Weight: 560.674
• Mol file: 445384-31-6.mol

Synonyms:

Chemical Property of isopropyl 6-amino-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4-(3,5-dimethoxyphenyl)-4H-pyran-3-carboxylate

Chemical Property:

Purity/Quality:

ISOPROPYL 6-AMINO-5-CYANO-2-(((3-CYANO-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTA(B)PYRIDIN-2-YL)SULFANYL)METHYL)-4-(3,5-DIMETHOXYPHENYL)-4H-PYRAN-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of isopropyl 6-amino-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4-(3,5-dimethoxyphenyl)-4H-pyran-3-carboxylate

There total 4 articles about isopropyl 6-amino-5-cyano-2-{[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)sulfanyl]methyl}-4-(3,5-dimethoxyphenyl)-4H-pyran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

β,β-dicyano-3,5-dimethoxystyrene (26495-19-2) + 4-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanyl)-3-oxo-butyric acid isopropyl ester (488725-51-5) → 6-amino-5-cyano-2-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanylmethyl)-4-(3,5-dimethoxy-phenyl)-4H-pyran-3-carboxylic acid isopropyl ester (445384-31-6)

Guidance literature:

With triethylamine; In ethanol; Heating;

DOI:10.1023/B:RUCB.0000011877.60574.34

Reference yield:

2-thioxo-2,5,6,7,8,9-hexahydro-1H-cyclohepta[b]pyridine-3-carbonitrile (123413-84-3) → 6-amino-5-cyano-2-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanylmethyl)-4-(3,5-dimethoxy-phenyl)-4H-pyran-3-carboxylic acid isopropyl ester (445384-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / Et₃N / ethanol / Heating

With triethylamine; In ethanol;

DOI:10.1023/B:RUCB.0000011877.60574.34

Reference yield:

4-chloroacetoacetic acid isopropyl ester (41051-20-1) → 6-amino-5-cyano-2-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanylmethyl)-4-(3,5-dimethoxy-phenyl)-4H-pyran-3-carboxylic acid isopropyl ester (445384-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / Et₃N / ethanol / Heating

With triethylamine; In ethanol;

DOI:10.1023/B:RUCB.0000011877.60574.34

upstream raw materials:

β,β-dicyano-3,5-dimethoxystyrene

4-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanyl)-3-oxo-butyric acid isopropyl ester

3,5-dimethoxybenzaldehdye

malononitrile

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