26495-19-2

Basic information

• Product Name: (3,5-dimethoxybenzylidene)propanedinitrile
• Synonyms: propanedinitrile, 2-[(3,5-dimethoxyphenyl)methylene]-
• CAS NO: 26495-19-2
• Molecular Formula: C₁₂H₁₀N₂O₂
• Molecular Weight: 214.22
• Mol File: 26495-19-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 386.6°C at 760 mmHg
• Flash Point: 160.5°C
• Density: 1.18g/cm³
• Vapor Pressure: 3.51E-06mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: (3,5-dimethoxybenzylidene)propanedinitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-dimethoxybenzylidene)propanedinitrile(26495-19-2)
• EPA Substance Registry System: (3,5-dimethoxybenzylidene)propanedinitrile(26495-19-2)

Safety Data

• Hazardous Substances Data: 26495-19-2(Hazardous Substances Data)

Usage

General Description

(3,5-dimethoxybenzylidene)propanedinitrile is a chemical compound consisting of a benzylidene group attached to a propanedinitrile molecule, with methoxy groups located at the 3 and 5 positions of the benzene ring. (3,5-dimethoxybenzylidene)propanedinitrile is commonly used in organic synthesis and pharmaceutical research, as it possesses interesting pharmacological properties and biological activities. It has been studied for its potential as an anti-cancer and anti-inflammatory agent, and has been used in the development of new drugs. Additionally, its unique chemical structure allows for it to participate in various reactions and catalytic processes, making it a valuable building block in the field of organic chemistry. Overall, (3,5-dimethoxybenzylidene)propanedinitrile is a versatile and important compound with many potential applications in the fields of medicine and chemical synthesis.

Upstream product

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 109-77-3 malononitrile 
• 922-64-5 1,1-dicyanoethylene 

Downstream Products

• 771559-24-1 2-(3,5-dimethoxybenzyl)malononitrile 
• 1379679-65-8 N-[2-bromo-2,2-dicyano-1-(3,5-dimethoxyphenyl)ethyl]pyrrolidine-2,5-dione 
• 445384-31-6 6-amino-5-cyano-2-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanylmethyl)-4-(3,5-dimethoxy-phenyl)-4H-pyran-3-carboxylic acid isopropyl ester 
• 118409-64-6 AG 83 

Relevant articles and documents

NaHCO3-Catalyzed Hihgly Regiospecific Aminobromination of ?,?-Dicyanostyrene Derivatives with 1,3-Dibromo-5,5-dimethylhydantoin (DBDMH)

The aminobromination of β,β-dicyanostyrene derivetives with 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) has been systematic studied. The reaction afforded the vicinal haloamino products in good to excellent yields at room temperature (the highest yield was up to 94 %), and the full regiospecificity of all products were achieved catalyzed by NaHCO3 in CH3CN. A possible pathway involving a Michael Addition reaction for this aminobromination was proposed. A new method for the NaHCO3-catalyzed aminobromination of β,β-dicyanostyrene derivatives with 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) has been developed. The reaction afforded the vicinal haloamino products in good to excellent yields at room temperature(the highest yield was up to 94 %). A possible pathway involving a Michael addition fashion for this aminobromination was proposed.

Defect engineering of highly stable lanthanide metal-organic frameworks by particle modulation for coating catalysis

By virtue of their structural periodicity, tunability, high porosity and rich functionality, metal-organic frameworks (MOFs) are of great interest in catalysis. However, MOF crystals are fragile and difficult to use as robust adsorbents or catalysts witho

Sodium acetate-catalyzed regiospecific and high stereoselective aminobromination of β,β-dicyanostyrene derivatives with NBS as nitrogen/bromine source

An easy and efficient method for the aminobromination of β,β-dicyanostyrene derivatives with NBS as the aminobrominating reagent in CH3CN catalyzed by NaOAc (10 mol%) is developed. This protocol provides convenient process to convert β,β-dicyanostyrene derivatives into the vicinal haloamines with full regiospecificity and high stereoselectivety in the ice-water bath in air. The reaction is high efficient in yielding the corresponding aminobrominated products in excellent yields (up to 95%) under these conditions. The outcome indicated that the reaction has an electrophilic addition feature. 12 Eexamples of β,β-dicyanostyrene derivatives have been investigated. An easy and efficient method for the aminobromination of β,β-dicyanostyrene derivatives with NBS as the aminobrominating reagent in CH3CN catalyzed by NaOAc (10 mol%) is developed. The reaction is high efficient in yielding the corresponding aminobrominated products in excellent yields (up to 95%). Copyright