N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl) (E)-3-C-allyl-1-(6-amino-N6-trityl-9H-purin-9-yl)-2-O-tert-butyldimethylsilyl-3,5,6-dideoxy-β-D-ribo-5-eneheptofuranuronamide

Base Information

Chemical Name:N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl) (E)-3-C-allyl-1-(6-amino-N6-trityl-9H-purin-9-yl)-2-O-tert-butyldimethylsilyl-3,5,6-dideoxy-β-D-ribo-5-eneheptofuranuronamide
CAS No.:1341219-72-4
Molecular Formula:C₆₈H₈₆N₆O₁₀Si₂
Molecular Weight:1203.64
Hs Code.:

N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl) (E)-3-C-allyl-1-(6-amino-N6-trityl-9H-purin-9-yl)-2-O-tert-butyldimethylsilyl-3,5,6-dideoxy-β-D-ribo-5-eneheptofuranuronamide

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Chemical Property of N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl) (E)-3-C-allyl-1-(6-amino-N6-trityl-9H-purin-9-yl)-2-O-tert-butyldimethylsilyl-3,5,6-dideoxy-β-D-ribo-5-eneheptofuranuronamide

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Technology Process of N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl) (E)-3-C-allyl-1-(6-amino-N6-trityl-9H-purin-9-yl)-2-O-tert-butyldimethylsilyl-3,5,6-dideoxy-β-D-ribo-5-eneheptofuranuronamide

There total 1 articles about N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl) (E)-3-C-allyl-1-(6-amino-N6-trityl-9H-purin-9-yl)-2-O-tert-butyldimethylsilyl-3,5,6-dideoxy-β-D-ribo-5-eneheptofuranuronamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₄₃N₅O₃Si

: 1341219-64-4
N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)diethylphosphonoacetamide

: 1341219-72-4
N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl) (E)-3-C-allyl-1-(6-amino-N6-trityl-9H-purin-9-yl)-2-O-tert-butyldimethylsilyl-3,5,6-dideoxy-β-D-ribo-5-eneheptofuranuronamide

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; zinc trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/jo201495w

Reference yield: 91.0%

: 1341219-72-4
N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl) (E)-3-C-allyl-1-(6-amino-N6-trityl-9H-purin-9-yl)-2-O-tert-butyldimethylsilyl-3,5,6-dideoxy-β-D-ribo-5-eneheptofuranuronamide

: 1341219-76-8
C₆₆H₈₂N₆O₁₀Si₂

: 1341219-74-6
C₆₆H₈₂N₆O₁₀Si₂

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; for 7h; Reflux;
DOI:10.1021/jo201495w

Reference yield:

: 1341219-72-4
N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl) (E)-3-C-allyl-1-(6-amino-N6-trityl-9H-purin-9-yl)-2-O-tert-butyldimethylsilyl-3,5,6-dideoxy-β-D-ribo-5-eneheptofuranuronamide

: 1341219-80-4
C₅₄H₅₄N₆O₁₀

Guidance literature:: Multi-step reaction with 2 steps

1: Grubbs catalyst first generation / dichloromethane / 7 h / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

With Grubbs catalyst first generation; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo201495w