N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)diethylphosphonoacetamide

Base Information

Chemical Name:N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)diethylphosphonoacetamide
CAS No.:1341219-64-4
Molecular Formula:C₃₄H₅₄NO₁₁PSi
Molecular Weight:711.862
Hs Code.:

Synonyms:N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)diethylphosphonoacetamide

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Chemical Property of N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)diethylphosphonoacetamide

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Technology Process of N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)diethylphosphonoacetamide

There total 6 articles about N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)diethylphosphonoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1341219-95-1
N-(3-allyl-4-methoxy-2,5-dimethoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)bromoacetamide

: 122-52-1
triethyl phosphite

: 1341219-64-4
N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)diethylphosphonoacetamide

Guidance literature:: With triethylamine; In dichloromethane; at 100 ℃; for 4h;
DOI:10.1021/jo201495w

Reference yield:

: 1341219-92-8
N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)-3-allyl-4-methoxy-2,5-dimethoxymethoxyaniline

: 1341219-64-4
N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)diethylphosphonoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C

2: triethylamine / dichloromethane / 4 h / 100 °C

With triethylamine; In dichloromethane; 2: Arbuzov reaction;
DOI:10.1021/jo201495w

Reference yield:

: 129742-36-5
(4-((tert-butyldimethylsilyl)oxy)-2-methoxybenzaldehyde)

: 1341219-64-4
N-(3-allyl-4-methoxy-2,5-bis-methoxymethoxyphenyl)-N-(4-tert-butyldimethylsiloxy-2-methoxybenzyl)diethylphosphonoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / dichloromethane / 0.17 h / 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 0.33 h / 0 - 20 °C

3: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C

4: triethylamine / dichloromethane / 4 h / 100 °C

With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In dichloromethane; 4: Arbuzov reaction;
DOI:10.1021/jo201495w