(+)-1-nitro-2-propanol

Base Information

• Chemical Name: (+)-1-nitro-2-propanol
• CAS No.: 63599-02-0
• Molecular Formula: C₃H₇NO₃
• Molecular Weight: 105.093
• Mol file: 63599-02-0.mol

Synonyms:

Chemical Property of (+)-1-nitro-2-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-1-nitro-2-propanol

There total 5 articles about (+)-1-nitro-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

nitromethane (75-52-5) + acetaldehyde (75-07-0,9002-91-9) → (S)-1-nitro-2-propanol (164203-06-9) + (R)-1-nitro-2-propanol (3156-73-8,63599-02-0)

Guidance literature:

With C₆₃H₆₈N₄O₃⁽²⁺⁾*2Br^(1-); sodium carbonate; In cyclohexane; water; at 30 ℃; for 1h; Reagent/catalyst; enantioselective reaction;

DOI:10.1039/c6ob01687a

Reference yield: 43.3%

vinyl acetate (108-05-4,9003-20-7) + 2-hydroxy-1-nitropropane (3156-73-8) → (+)-1-nitro-2-propanol (3156-73-8,63599-02-0) + (+)-1-nitro-2-acetoxypropane (3156-76-1,137695-17-1)

Guidance literature:

In hexane; at 30 ℃; for 5h; lipase, Amano AK; other solvents, stereoselectivity;

DOI:10.1016/S0040-4039(00)93502-0

Reference yield:

(R)-1-nitropropan-2-yl acetate → (R)-1-nitro-2-propanol (3156-73-8,63599-02-0)

Guidance literature:

With acetyl chloride; In methanol; at 0 - 23 ℃; for 2.25h;

upstream raw materials:

2-hydroxy-1-nitropropane

succinic acid anhydride

nitromethane

acetaldehyde

Downstream raw materials:

((R)-1-Methyl-2-nitro-ethoxymethyl)-benzene

(-)-1-nitro-2-acetoxypropane