(4aS,13bS)-2,3,4,4a,5,6,8,9-Octahydro-1H-indolo[7a,1-a]isoquinoline

Base Information

Chemical Name:(4aS,13bS)-2,3,4,4a,5,6,8,9-Octahydro-1H-indolo[7a,1-a]isoquinoline
CAS No.:27711-98-4
Molecular Formula:C₁₆H₂₁N
Molecular Weight:227.349
Hs Code.:
Mol file:27711-98-4.mol

Synonyms:1H-Indolo[7a,1-a]isoquinoline,erythrinan deriv.;(4aS,13bS)-2,3,4,4a,5,6,8,9-Octahydro-1H-indolo[7a,1-a]isoquinoline;1H-Indolo[7a,1-a]isoquinoline, 2,3,4,4a,5,6,8,9-octahydro-, (4aS,13bS)-

Suppliers and Price of (4aS,13bS)-2,3,4,4a,5,6,8,9-Octahydro-1H-indolo[7a,1-a]isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (4aS,13bS)-2,3,4,4a,5,6,8,9-Octahydro-1H-indolo[7a,1-a]isoquinoline

Chemical Property:

PSA：3.24000
LogP:3.27180

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4aS,13bS)-2,3,4,4a,5,6,8,9-Octahydro-1H-indolo[7a,1-a]isoquinoline

There total 18 articles about (4aS,13bS)-2,3,4,4a,5,6,8,9-Octahydro-1H-indolo[7a,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 809233-37-2
1-[2-(2-iodophenyl)ethyl]octahydroindole-7a-carbonitrile

: 17459-91-5,27711-98-4,27766-33-2,33875-50-2
cis-erythrinane

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at -50 - 60 ℃;
DOI:10.1007/s00706-004-0184-8

Reference yield:

: rac-erythrinan-10-one

: 17459-91-5,27711-98-4,27766-33-2,33875-50-2
cis-erythrinane

Guidance literature:: With lithium aluminium tetrahydride; diethyl ether;
DOI:10.1139/v57-095 DOI:10.1021/ja01118a531

Reference yield:

: 57133-56-9
2-(1,4-dioxaspiro[4.5]decan-6-yl)ethan-1-ol

: 17459-91-5,27711-98-4,27766-33-2,33875-50-2
cis-erythrinane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 0.5 h / -70 °C

2.1: 98 percent / toluene / 2 h / Heating

3.1: 66 percent / NaBH₄ / methanol / 2 h / Heating

4.1: aq. HCl / 1.5 h / 60 °C

4.2: 97 percent / H₂O / 1 h / 20 °C / pH 7 - 8

5.1: 75 percent / i-PrMgCl / tetrahydrofuran / -50 - 60 °C

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; isopropylmagnesium chloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; 1.1: Swern oxidation / 4.1: intramolecular Strecker reaction / 5.1: intramolecular Bruylants reaction;
DOI:10.1007/s00706-004-0184-8