Technology Process of (+/-)-3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoic acid
There total 10 articles about (+/-)-3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenylamino)butyl)benzamido)propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium hydroxide; water / methanol
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / tetrahydrofuran
3: lithium hydroxide; water / methanol
With
water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2013.03.014
- Guidance literature:
-
Multi-step reaction with 5 steps
1: palladium 10% on activated carbon; ammonium formate / ethanol; tetrahydrofuran
2: nido-decaborane / methanol / 0 °C
3: lithium hydroxide; water / methanol
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / tetrahydrofuran
5: lithium hydroxide; water / methanol
With
nido-decaborane; palladium 10% on activated carbon; water; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; ethanol;
DOI:10.1016/j.bmcl.2013.03.014
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / acetonitrile / 80 °C
2: palladium 10% on activated carbon; ammonium formate / ethanol; tetrahydrofuran
3: nido-decaborane / methanol / 0 °C
4: lithium hydroxide; water / methanol
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / tetrahydrofuran
6: lithium hydroxide; water / methanol
With
nido-decaborane; palladium 10% on activated carbon; water; ammonium formate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2013.03.014
