C₁₇H₁₈BrFN₂O

Base Information

Chemical Name:C₁₇H₁₈BrFN₂O
CAS No.:1617505-10-8
Molecular Formula:C₁₇H₁₈BrFN₂O
Molecular Weight:365.245
Hs Code.:

C<sub>17</sub>H<sub>18</sub>BrFN<sub>2</sub>O

Synonyms:

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Chemical Property of C₁₇H₁₈BrFN₂O

Chemical Property:

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Technology Process of C₁₇H₁₈BrFN₂O

There total 4 articles about C₁₇H₁₈BrFN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1555701-66-0
4-bromo-6-fluoro-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

: 1617505-10-8
C₁₇H₁₈BrFN₂O

Guidance literature:: With ammonium chloride; zinc; In methanol; ethyl acetate; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm5006226

Reference yield:

: 239122-51-1
5-bromo-3-fluoro-2-methoxyaniline

: 1617505-10-8
C₁₇H₁₈BrFN₂O

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / -10 °C / Inert atmosphere

2.1: dichloromethane / 20 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere

2.3: 0.17 h / 0 °C / Inert atmosphere

3.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / Inert atmosphere; Sealed tube

4.1: zinc; ammonium chloride / methanol; ethyl acetate / 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; sodium nitrite; In methanol; dichloromethane; water; ethyl acetate; toluene; 2.1: |Fischer Indole Synthesis;
DOI:10.1021/jm5006226

Reference yield:

: 1379365-84-0
C₇H₈BrFN₂O

: 1617505-10-8
C₁₇H₁₈BrFN₂O

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 20 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere

1.3: 0.17 h / 0 °C / Inert atmosphere

2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / Inert atmosphere; Sealed tube

3.1: zinc; ammonium chloride / methanol; ethyl acetate / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; In methanol; dichloromethane; ethyl acetate; toluene; 1.1: |Fischer Indole Synthesis;
DOI:10.1021/jm5006226