2-[2-Amino-4-(benzyloxy)phenyl]propane-1,3-diol

Base Information

Chemical Name:2-[2-Amino-4-(benzyloxy)phenyl]propane-1,3-diol
CAS No.:106014-84-0
Molecular Formula:C16H19NO3
Molecular Weight:273.332
Hs Code.:
DSSTox Substance ID:DTXSID80546294
Wikidata:Q82424091

Synonyms:106014-84-0;2-[2-Amino-4-(benzyloxy)phenyl]propane-1,3-diol;SCHEMBL10846153;DTXSID80546294

Suppliers and Price of 2-[2-Amino-4-(benzyloxy)phenyl]propane-1,3-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[2-Amino-4-(benzyloxy)phenyl]propane-1,3-diol

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:273.13649347
Heavy Atom Count:20
Complexity:264

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=CC(=C(C=C2)C(CO)CO)N

Technology Process of 2-[2-Amino-4-(benzyloxy)phenyl]propane-1,3-diol

There total 6 articles about 2-[2-Amino-4-(benzyloxy)phenyl]propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 106014-83-9
2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol

: 106014-84-0
2-<2-amino-4-(benzyloxy)phenyl>propane-1,3-diol

Guidance literature:: With hydrogen; platinum(IV) oxide;
DOI:10.1016/S0040-4039(00)84921-7

Reference yield:

: 112089-51-7
diethyl <4-(benzyloxy)-2-nitrophenyl>malonate

: 106014-84-0
2-<2-amino-4-(benzyloxy)phenyl>propane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / diisobutylaluminum hydride / tetrahydrofuran / 2.3 h / Ambient temperature

2: 69 percent / hydrogen / 84.5percent PtO₂ / ethanol / 2.75 h / 2327.2 Torr

With hydrogen; diisobutylaluminium hydride; platinum(IV) oxide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00398a017

Reference yield:

: 79035-13-5
4-benzyloxy-2-nitro-chlorobenzene

: 106014-84-0
2-<2-amino-4-(benzyloxy)phenyl>propane-1,3-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / NaH / dimethylsulfoxide / 24 h / 105 - 115 °C

2: 40 percent / diisobutylaluminum hydride / tetrahydrofuran / 2.3 h / Ambient temperature

3: 69 percent / hydrogen / 84.5percent PtO₂ / ethanol / 2.75 h / 2327.2 Torr

With hydrogen; sodium hydride; diisobutylaluminium hydride; platinum(IV) oxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00398a017