112089-51-7

Upstream product

• 79035-13-5 4-benzyloxy-2-nitro-chlorobenzene 
• 105-53-3 diethyl malonate 
• 4514-28-7 2-Bromo-5-benzyloxy-nitrobenzene 
• 100-39-0 benzyl bromide 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 
• 996-82-7 sodium diethylmalonate 
• 610-78-6 3-nitro-4-chlorophenol 

Downstream Products

• 89553-54-8 C₁₃H₁₄N₂O₃S 
• 151384-96-2 6-benzyloxy-1-(N-methyl-2-pyrrolecarboxy)-3-methanesulfonyloxymethylindole 
• 151384-95-1 6-benzyloxy-3-hydroxymethyl-1-(N-methyl-2-pyrrolecarboxy)indole 
• 366789-52-8 6-benzyloxy-3-hydroxymethyl-2,3-dihydro-1H-indole 
• 132628-58-1 3-acetoxymethyl-6-benzyloxy-1-t-butoxycarbonyl-2,3-dihydro-1H-indole 
• 151384-87-1 6-benzyloxy-1-tert-butyloxycarbonyl-2,3-dihydro-1H-indole-3-methanol 
• 112089-99-3 Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester 
• 112089-98-2 Methanesulfonic acid 5-benzyloxy-8-methyl-3-{5-[(5-ureido-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester 
• 101134-52-5 5-Benzoylamino-1H-indole-2-carboxylic acid [2-(5-benzyloxy-1-hydroxymethyl-8-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indole-3-carbonyl)-1H-indol-5-yl]-amide 
• 101134-53-6 5-Ureido-1H-indole-2-carboxylic acid [2-(5-benzyloxy-1-hydroxymethyl-8-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indole-3-carbonyl)-1H-indol-5-yl]-amide 
• 112243-85-3 Methanesulfonic acid 5-benzyloxy-3-{4-[(1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester 
• 112089-50-6 C₃₇H₂₈N₆O₄ 
• 112243-84-2 5-(benzyloxy)-1,2,3,6-tetrahydro-8-methyl-3-<<5-<(1H-indol-2-ylcabonyl)amino>-1H-indol-2-yl>carbonyl>benzo<1,2-b:4,3-b'>dipyrrole-1-methanol 
• 112089-95-9 Methanesulfonic acid 5-benzyloxy-8-methyl-3-(5-ureido-1H-indole-2-carbonyl)-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester 

Relevant academic research and scientific papers

Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds

The duocarmycins belong to a class of agent which has great potential for use in cancer therapy. Their exquisite potency means they are too toxic for systemic use, and targeted approaches are required to unlock their clinical potential. In this study, we

Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

1 H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of -disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

AN ALTERNATIVE METHOD FOR SYNTHESIS OF THE CC-1065 PHARMACOPHORE, 1,2,7,7a-TETRAHYDROCYCLOPROPINDOL-4-ONE

The synthesis of the CC-1065 pharmacophore, 2-(1-methylpyrrole-2-carbonyl)-1,2,7,7a-tetrahydrocyclopropindol-4-one (17), is described.The methods reported here provide an alternative route for the synthesis of compounds possessing the biologically

Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065

The synthesis, physicochemical properties, and biological activities of a series of novel spiro cyclopropyl compounds, modeled on the potent antitumor antibiotic CC-1065 (1), are described. Many of these synthetic analogues are significantly more effectiv