SAR131675

Base Information

Chemical Name:SAR131675
CAS No.:1092538-80-1
Molecular Formula:C₁₈H₂₂N₄O₄
Molecular Weight:358.397
Hs Code.:
Mol file:1092538-80-1.mol

Synonyms:

Suppliers and Price of SAR131675

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SAR131675
25mg
$ 170.00

Medical Isotopes, Inc.
SAR131675
500 mg
$ 2750.00

Total 1 raw suppliers

Chemical Property of SAR131675

Chemical Property:

Purity/Quality:: SAR131675 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the prolife ration of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD. SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD.

Technology Process of SAR131675

There total 1 articles about SAR131675 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 42841-64-5
1-methoxy-2-methyl-but-3-yn-2-ol

: 1092523-24-4
2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

: 1092538-80-1,1092539-44-0,1092539-45-1
(+/-)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:: 1-methoxy-2-methyl-but-3-yn-2-ol; 2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; With triethylamine; copper(l) iodide; tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 90 ℃; Microwave irradiation; Inert atmosphere; Sealed tube;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;