(S)-2-[(1-{(2S,3S)-2-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-6-(benzyloxy-formyl-amino)-hexanoic acid

Base Information

Chemical Name:(S)-2-[(1-{(2S,3S)-2-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-6-(benzyloxy-formyl-amino)-hexanoic acid
CAS No.:727426-61-1
Molecular Formula:C₃₆H₅₁N₅O₈
Molecular Weight:681.83
Hs Code.:

(S)-2-[(1-{(2S,3S)-2-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-6-(benzyloxy-formyl-amino)-hexanoic acid

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Chemical Property of (S)-2-[(1-{(2S,3S)-2-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-6-(benzyloxy-formyl-amino)-hexanoic acid

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Technology Process of (S)-2-[(1-{(2S,3S)-2-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-6-(benzyloxy-formyl-amino)-hexanoic acid

There total 11 articles about (S)-2-[(1-{(2S,3S)-2-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-6-(benzyloxy-formyl-amino)-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622-33-3
N-benzyloxyamine

: 727426-61-1
(S)-2-[(1-{(2S,3S)-2-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-6-(benzyloxy-formyl-amino)-hexanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: DIEA / methanol

2: trifluoroacetic acid

3: acylase

4: Et₃N

5: DCC; DMAP

6: trifluoroacetic acid

7: HBTU; HOBt*H₂O; Et₃N

8: TBAF / tetrahydrofuran

9: trifluoroacetic acid

With dmap; acylase; tetrabutyl ammonium fluoride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2004.03.018

Reference yield:

: 227185-30-0
N-acetyl-DL-2-amino-6-bromohexanoic acid

: 727426-61-1
(S)-2-[(1-{(2S,3S)-2-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-6-(benzyloxy-formyl-amino)-hexanoic acid

Guidance literature:: Multi-step reaction with 11 steps

1: DMAP

2: DIEA / methanol

3: trifluoroacetic acid

4: acylase

5: Et₃N

6: DCC; DMAP

7: trifluoroacetic acid

8: HBTU; HOBt*H₂O; Et₃N

9: TBAF / tetrahydrofuran

10: trifluoroacetic acid

With dmap; acylase; tetrabutyl ammonium fluoride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2004.03.018

Reference yield:

: 727426-13-3
2-acetylamino-6-bromo-hexanoic acid tert-butyl ester

: 727426-61-1
(S)-2-[(1-{(2S,3S)-2-[(R)-2-Amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-6-(benzyloxy-formyl-amino)-hexanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: DIEA / methanol

2: trifluoroacetic acid

3: acylase

4: Et₃N

5: DCC; DMAP

6: trifluoroacetic acid

7: HBTU; HOBt*H₂O; Et₃N

8: TBAF / tetrahydrofuran

9: trifluoroacetic acid

With dmap; acylase; tetrabutyl ammonium fluoride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2004.03.018