Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

Base Information

• Chemical Name: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]
• CAS No.: 106023-62-5
• Molecular Formula: C39H49N6O6P
• Molecular Weight: 728.828
• Mol file: 106023-62-5.mol

Synonyms:

Chemical Property of Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite]

There total 3 articles about Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyl-, 3'-[methyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

bis(N,N-diisopropylamino)methoxyphosphine (92611-10-4) + 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N6-methyladenosine (98056-69-0) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-methylamino-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester (106023-62-5)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane;

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-methylamino-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester (106023-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dimethylformamide

2: 100 percent / diisopropylamine hydrotetrazolide / CH₂Cl₂

With N,N-diisopropylamine tetrazolide; In pyridine; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

N-6-methyl-2'-deoxyribofuranosil adenine (2002-35-9) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-methylamino-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester (106023-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dimethylformamide

2: 100 percent / diisopropylamine hydrotetrazolide / CH₂Cl₂

With N,N-diisopropylamine tetrazolide; In pyridine; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

bis(N,N-diisopropylamino)methoxyphosphine

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁶-methyladenosine

4,4'-dimethoxytrityl chloride

N-6-methyl-2'-deoxyribofuranosil adenine

Refernces