C₂₉H₃₂N₆O₄Si

Base Information

• Chemical Name: C₂₉H₃₂N₆O₄Si
• CAS No.: 1273196-85-2
• Molecular Formula: C₂₉H₃₂N₆O₄Si
• Molecular Weight: 556.696
• Mol file: 1273196-85-2.mol

Synonyms:

Chemical Property of C₂₉H₃₂N₆O₄Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₂N₆O₄Si

There total 6 articles about C₂₉H₃₂N₆O₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-[3-bromo-5-O-tert-butyldiphenylsilyl-3-deoxy-2-O-(N-vinylcarbamoyl)-β-D-xylofuranosyl]adenine (1273196-83-0) → C29H32N6O4Si (1273196-85-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at -20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jo102178h

Reference yield:

9-(2,3-anhydro-β-D-ribofuranosyl)adenine (2627-64-7) → C29H32N6O4Si (1273196-85-2)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 20 °C / Inert atmosphere

2: dimethylboron bromide; triethylamine / dichloromethane / -78 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran; acetonitrile / 48 h / 20 °C / Inert atmosphere

4: sodium hydride / tetrahydrofuran / 12 h / -20 °C / Inert atmosphere

With pyridine; dimethylboron bromide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/jo102178h

Reference yield:

9-<3-bromo-5-O-<(tert-butyl)diphenylsilyl>-3-deoxy-β-D-xylofuranosyl>adenine (125084-68-6) → C29H32N6O4Si (1273196-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran; acetonitrile / 48 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 12 h / -20 °C / Inert atmosphere

With sodium hydride; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jo102178h

upstream raw materials:

9-[3-bromo-5-O-tert-butyldiphenylsilyl-3-deoxy-2-O-(N-vinylcarbamoyl)-β-D-xylofuranosyl]adenine

9-(2,3-anhydro-β-D-ribofuranosyl)adenine

9-<2,3-anhydro-5-O-<(tert-butyl)diphenylsilyl>-β-D-ribofuranosyl>adenine

9-<3-bromo-5-O-<(tert-butyl)diphenylsilyl>-3-deoxy-β-D-xylofuranosyl>adenine

Downstream raw materials:

3'-amino-5'-O-(tert-butyldiphenylsilyl)-3-deoxyadenosine

5'-O-(tert-butyldiphenylsilyl)-3'-[N-(9-fluorenyl)methoxycarbonyl-O-methyl-L-tyrosyl]amido-3'-deoxyadenosine

3'-L-(p-methoxyphenylalanylamino)-3'-deoxy-β-D-adenosine