(4R,6S)-(-)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester

Base Information

• Chemical Name: (4R,6S)-(-)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester
• CAS No.: 1268637-61-1
• Molecular Formula: C₄₂H₃₉NO₆S
• Molecular Weight: 685.841
• Mol file: 1268637-61-1.mol

Synonyms:

Chemical Property of (4R,6S)-(-)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,6S)-(-)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester

There total 2 articles about (4R,6S)-(-)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-methoxynaphthalen-1-yl)propynoic acid isopropyl ester (1197907-35-9) + N-but-2-ynyl-N-[3-(2-methoxynaphthalen-1-yl)prop-2-ynyl]-4-methylbenzenesulfonamide (1268492-53-0) → (4S,6R)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester (1268637-61-1,1268637-57-5) + (4R,6S)-(-)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester (1268637-61-1,1268637-57-5) + 4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester + (-)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester

Guidance literature:

With (S)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(diphenylphosphine); bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; In dichloromethane; at 20 ℃; for 3h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jo1024255

Reference yield:

(2-methoxynaphthalen-1-yl)propynoic acid isopropyl ester (1197907-35-9) + N-but-2-ynyl-N-[3-(2-methoxynaphthalen-1-yl)prop-2-ynyl]-4-methylbenzenesulfonamide (1268492-53-0) → (4S,6R)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester (1268637-61-1,1268637-57-5) + (4R,6S)-(-)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester (1268637-61-1,1268637-57-5) + 4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester + (-)-4,6-bis(2-methoxynaphthalen-1-yl)-7-methyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid isopropyl ester

Guidance literature:

With (S)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(diphenylphosphine); bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; In dichloromethane; at 20 ℃; for 3h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jo1024255

upstream raw materials:

(2-methoxynaphthalen-1-yl)propynoic acid isopropyl ester

N-but-2-ynyl-N-[3-(2-methoxynaphthalen-1-yl)prop-2-ynyl]-4-methylbenzenesulfonamide