Technology Process of hexestrol-coumarin-3-carboxylic acid
There total 4 articles about hexestrol-coumarin-3-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / 1N NaOH / H2O / 3 h / 0 °C
2: 83 percent / conc. HCl / aq. ethanol / Heating
3: 91 percent / 1.) 1N aq. HCl; 2.) BBr3 / 1.) MeOH; 2.) CH2Cl2, -78 deg C
4: 81 percent / 30percent H2O2 / methanol / 72 h
5: 90 percent / 1.) trifluoroacetic anhydride; 2.) NaHCO3 / CH2Cl2 / 1.) RT, 2 h; 2.) pH=8
6: 95 percent / piperidine / acetic acid; ethanol / 3 h / Heating
7: 0.2N NaOH / ethanol; H2O / 1 h / Heating
With
piperidine; hydrogenchloride; sodium hydroxide; dihydrogen peroxide; boron tribromide; sodium hydrogencarbonate; trifluoroacetic anhydride;
In
methanol; ethanol; dichloromethane; water; acetic acid;
DOI:10.1016/0223-5234(87)90171-1
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 91 percent / 1.) 1N aq. HCl; 2.) BBr3 / 1.) MeOH; 2.) CH2Cl2, -78 deg C
2: 81 percent / 30percent H2O2 / methanol / 72 h
3: 90 percent / 1.) trifluoroacetic anhydride; 2.) NaHCO3 / CH2Cl2 / 1.) RT, 2 h; 2.) pH=8
4: 95 percent / piperidine / acetic acid; ethanol / 3 h / Heating
5: 0.2N NaOH / ethanol; H2O / 1 h / Heating
With
piperidine; hydrogenchloride; sodium hydroxide; dihydrogen peroxide; boron tribromide; sodium hydrogencarbonate; trifluoroacetic anhydride;
In
methanol; ethanol; dichloromethane; water; acetic acid;
DOI:10.1016/0223-5234(87)90171-1
