C-(2-Methoxy-4-methylsulfanyl-phenyl)-C-(4-methylsulfanyl-phenyl)-methylamine; compound with toluene-4-sulfonic acid

Base Information

• Chemical Name: C-(2-Methoxy-4-methylsulfanyl-phenyl)-C-(4-methylsulfanyl-phenyl)-methylamine; compound with toluene-4-sulfonic acid
• CAS No.: 136669-97-1
• Molecular Formula: C₇H₈O₃S*C₁₆H₁₉NOS₂
• Molecular Weight: 477.67
• Mol file: 136669-97-1.mol

Synonyms:

Chemical Property of C-(2-Methoxy-4-methylsulfanyl-phenyl)-C-(4-methylsulfanyl-phenyl)-methylamine; compound with toluene-4-sulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C-(2-Methoxy-4-methylsulfanyl-phenyl)-C-(4-methylsulfanyl-phenyl)-methylamine; compound with toluene-4-sulfonic acid

There total 11 articles about C-(2-Methoxy-4-methylsulfanyl-phenyl)-C-(4-methylsulfanyl-phenyl)-methylamine; compound with toluene-4-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-hydroxy-2-methoxybenzoate (28478-46-8) → C-(2-Methoxy-4-methylsulfanyl-phenyl)-C-(4-methylsulfanyl-phenyl)-methylamine; compound with toluene-4-sulfonic acid (136669-97-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF

2: aq. NaOH / 235 °C

3: 1.) NaH / 1.) DMF

4: SOCl₂

5: AlCl₃ / 1,2-dichloro-ethane / 50 °C

6: NH₂OH*HCl, NaOAc / ethanol

7: Zn, HOAc

With sodium hydroxide; aluminium trichloride; thionyl chloride; hydroxylamine hydrochloride; sodium acetate; sodium hydride; acetic acid; zinc; In ethanol; 1,2-dichloro-ethane;

DOI:10.1016/S0040-4039(00)79406-8

Reference yield:

4-hydroxysalicylic acid (89-86-1) → C-(2-Methoxy-4-methylsulfanyl-phenyl)-C-(4-methylsulfanyl-phenyl)-methylamine; compound with toluene-4-sulfonic acid (136669-97-1)

Guidance literature:

Multi-step reaction with 11 steps

1: SOCl₂

2: NEt₃, DMAP / dimethylformamide

3: 1.) NaH / 1.) DMF

4: DOWEX 50X₂ / methanol

5: 1.) NaH / 1.) DMF

6: aq. NaOH / 235 °C

7: 1.) NaH / 1.) DMF

8: SOCl₂

9: AlCl₃ / 1,2-dichloro-ethane / 50 °C

10: NH₂OH*HCl, NaOAc / ethanol

11: Zn, HOAc

With dmap; sodium hydroxide; aluminium trichloride; thionyl chloride; Dowex 50x2; hydroxylamine hydrochloride; sodium acetate; sodium hydride; acetic acid; triethylamine; zinc; In methanol; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)79406-8

Reference yield:

methyl 2,4-dihydroxybenzoate (2150-47-2) → C-(2-Methoxy-4-methylsulfanyl-phenyl)-C-(4-methylsulfanyl-phenyl)-methylamine; compound with toluene-4-sulfonic acid (136669-97-1)

Guidance literature:

Multi-step reaction with 10 steps

1: NEt₃, DMAP / dimethylformamide

2: 1.) NaH / 1.) DMF

3: DOWEX 50X₂ / methanol

4: 1.) NaH / 1.) DMF

5: aq. NaOH / 235 °C

6: 1.) NaH / 1.) DMF

7: SOCl₂

8: AlCl₃ / 1,2-dichloro-ethane / 50 °C

9: NH₂OH*HCl, NaOAc / ethanol

10: Zn, HOAc

With dmap; sodium hydroxide; aluminium trichloride; thionyl chloride; Dowex 50x2; hydroxylamine hydrochloride; sodium acetate; sodium hydride; acetic acid; triethylamine; zinc; In methanol; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)79406-8

upstream raw materials:

toluene-4-sulfonic acid

methyl 4-hydroxy-2-methoxybenzoate

4-hydroxysalicylic acid

methyl 2,4-dihydroxybenzoate

Downstream raw materials:

({[(4-Methanesulfinyl-2-methoxy-phenyl)-(4-methanesulfinyl-phenyl)-methyl]-carbamoyl}-methyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

({[(2-Methoxy-4-methylsulfanyl-phenyl)-(4-methylsulfanyl-phenyl)-methyl]-carbamoyl}-methyl)-carbamic acid 9H-fluoren-9-ylmethyl ester