(2S,3R,4R,5S)-2,5-Diamino-1,6-diphenyl-3,4-hexanediol Dihydrochloride

Base Information

Chemical Name:(2S,3R,4R,5S)-2,5-Diamino-1,6-diphenyl-3,4-hexanediol Dihydrochloride
CAS No.:137649-86-6
Molecular Formula:C₁₈H₂₄N₂O₂*2ClH
Molecular Weight:373.323
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4R,5S)-2,5-Diamino-1,6-diphenyl-3,4-hexanediol Dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,3R,4R,5S)-2,5-Diamino-1,6-diphenyl-3,4-hexanediol Dihydrochloride

There total 4 articles about (2S,3R,4R,5S)-2,5-Diamino-1,6-diphenyl-3,4-hexanediol Dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 137649-69-5
(2S,3R,4R,5S)-2,5-bis<<(benzyloxy)carbonyl>amino>-3,4-dihydroxy-1,6-diphenylhexane

: 137649-86-6,137894-62-3
(2S,3R,4R,5S)-2,5-Diamino-1,6-diphenyl-3,4-hexanediol Dihydrochloride

Guidance literature:: With hydrogenchloride; formic acid; palladium on activated charcoal; 1) MeOH, 6 h, 2) Et₂O/toluene;
DOI:10.1021/jo00027a009

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 137649-86-6,137894-62-3
(2S,3R,4R,5S)-2,5-Diamino-1,6-diphenyl-3,4-hexanediol Dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / H₂O

2: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -63 deg C, 20 min, 2) -63 deg C, 20 min

3: 1) 2Cl₃(THF)6>22Cl₆>, 2) 1 M HCl / 1) CH₂Cl₂, 3 h, 2) CH₂Cl₂/THF, 12 h

4: 97 percent / 1) 95percent formic acid, 2) HCl gas / 1) 10percent Pd/C / 1) MeOH, 6 h, 2) Et₂O/toluene

With hydrogenchloride; formic acid; oxalyl dichloride; 2; potassium carbonate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In water;
DOI:10.1021/jo00027a009

Reference yield:

: 59830-60-3
benzyl (1S)-(1-formyl-2-phenylethyl)carbamate

: 137649-86-6,137894-62-3
(2S,3R,4R,5S)-2,5-Diamino-1,6-diphenyl-3,4-hexanediol Dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1) 2Cl₃(THF)6>22Cl₆>, 2) 1 M HCl / 1) CH₂Cl₂, 3 h, 2) CH₂Cl₂/THF, 12 h

2: 97 percent / 1) 95percent formic acid, 2) HCl gas / 1) 10percent Pd/C / 1) MeOH, 6 h, 2) Et₂O/toluene

With hydrogenchloride; formic acid; 2; palladium on activated charcoal;
DOI:10.1021/jo00027a009