Technology Process of N-(3-phenylpentan-3-yl)piperidine-4-carboxamide hydrochloride
There total 5 articles about N-(3-phenylpentan-3-yl)piperidine-4-carboxamide hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
water; ethyl acetate;
at 20 ℃;
for 2h;
Cooling with ice;
DOI:10.1248/cpb.59.1376
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran; diethyl ether / 2 h / -20 - 0 °C
2: sulfuric acid / acetic acid / 4 h / 20 °C / Cooling with ice
3: acetic acid; thiourea / ethanol / 16 h / Reflux
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 72 h / 20 °C / Cooling with ice
5: hydrogenchloride / water; ethyl acetate / 2 h / 20 °C / Cooling with ice
With
hydrogenchloride; sulfuric acid; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; thiourea;
In
tetrahydrofuran; diethyl ether; ethanol; water; acetic acid; ethyl acetate; acetonitrile;
2: Ritter reaction;
DOI:10.1248/cpb.59.1376
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sulfuric acid / acetic acid / 4 h / 20 °C / Cooling with ice
2: acetic acid; thiourea / ethanol / 16 h / Reflux
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 72 h / 20 °C / Cooling with ice
4: hydrogenchloride / water; ethyl acetate / 2 h / 20 °C / Cooling with ice
With
hydrogenchloride; sulfuric acid; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; thiourea;
In
ethanol; water; acetic acid; ethyl acetate; acetonitrile;
1: Ritter reaction;
DOI:10.1248/cpb.59.1376
