Acetic acid (4aR,5S,8aR)-8a-[(Z)-(R)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester

Base Information

• Chemical Name: Acetic acid (4aR,5S,8aR)-8a-[(Z)-(R)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester
• CAS No.: 145387-81-1
• Molecular Formula: C₃₁H₄₃NO₇
• Molecular Weight: 541.685

Synonyms:

Chemical Property of Acetic acid (4aR,5S,8aR)-8a-[(Z)-(R)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (4aR,5S,8aR)-8a-[(Z)-(R)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester

There total 18 articles about Acetic acid (4aR,5S,8aR)-8a-[(Z)-(R)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

Acetic acid (4aR,5S,8aR)-8a-[2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-ynyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester (145387-80-0,145416-66-6) → Acetic acid (4aR,5S,8aR)-8a-[(Z)-(S)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester (145387-81-1,145416-65-5) + Acetic acid (4aR,5S,8aR)-8a-[(Z)-(R)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester (145387-81-1,145416-65-5)

Guidance literature:

With pyridine; hydrogen; barium sulfate;

DOI:10.1016/S0040-4039(00)60944-9

Reference yield: 32.0%

Acetic acid (4aR,5S,8aR)-8a-[2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-ynyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester (145387-80-0,145416-66-6) → Acetic acid (4aR,5S,8aR)-8a-[(Z)-(S)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester (145387-81-1,145416-65-5) + Acetic acid (4aR,5S,8aR)-8a-[(Z)-(R)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester (145387-81-1,145416-65-5)

Guidance literature:

With pyridine; hydrogen; barium sulfate;

DOI:10.1016/S0040-4039(00)60944-9

Reference yield:

1-(2-Methoxy-ethyl)-cyclohexa-2,5-dienecarboxylic acid (124981-58-4) → Acetic acid (4aR,5S,8aR)-8a-[(Z)-(S)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester (145387-81-1,145416-65-5)

Guidance literature:

Multi-step reaction with 9 steps

1: 1) (PhO)2P(=O)N₃, Et₃N, pyrrolidine; 2) I₂, H₂O / 2) THF

2: 2,2'-azobisisobutyronitrile / benzene / Ambient temperature

4: 4-(N,N-dimethylamino)pyridine, pyridine

6: BBr₃

7: Swern oxidation

9: 68 percent / H₂, pyridine / BaSO₄

With pyrrolidine; pyridine; dmap; 2,2'-azobis(isobutyronitrile); diphenyl phosphoryl azide; water; hydrogen; iodine; boron tribromide; triethylamine; barium sulfate; In benzene;

DOI:10.1016/S0040-4039(00)60944-9

upstream raw materials:

Acetic acid (4aR,5S,8aR)-8a-[2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-ynyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester

1-(2-Methoxy-ethyl)-cyclohexa-2,5-dienecarboxylic acid

(1R,5R,8R)-8-Iodo-1-(2-methoxy-ethyl)-6-oxa-bicyclo[3.2.1]oct-2-en-7-one

Acetic acid (4aS,5R,8aS)-2-(4-methoxy-phenyl)-1-oxo-8a-(2-oxo-ethyl)-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester

Downstream raw materials:

C₄₁H₆₄N₂O₁₀SSi

Acetic acid (4aR,5S,8aR)-2-(4-methoxy-phenyl)-1-oxo-8a-[(Z)-(S)-8-(toluene-4-sulfonyloxy)-2-(2-trimethylsilanyl-ethanesulfonylamino)-oct-3-enyl]-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester

(1aS,3R,3aS,7aR,7bR)-3-Methoxymethoxy-6-(4-methoxy-phenyl)-7a-[(Z)-(S)-1-(2-trimethylsilanyl-ethanesulfonyl)-1,2,5,6,7,8-hexahydro-azocin-2-ylmethyl]-octahydro-1-oxa-6-aza-cyclopropa[a]naphthalen-7-one

Acetic acid (4aR,5S,8aR)-2-(4-methoxy-phenyl)-1-oxo-8a-[(Z)-(R)-1-(2-trimethylsilanyl-ethanesulfonyl)-1,2,5,6,7,8-hexahydro-azocin-2-ylmethyl]-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 145387-81-1 Acetic acid (4aR,5S,8aR)-8a-[(Z)-(R)-2-hydroxy-8-(tetrahydro-pyran-2-yloxy)-oct-3-enyl]-2-(4-methoxy-phenyl)-1-oxo-1,2,3,4,4a,5,6,8a-octahydro-isoquinolin-5-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send