Technology Process of 9-hexyl-7-phenyl-1-tosyl-2,3,4,5,6,9-hexahydro-1H-benzo[b]azepine
There total 9 articles about 9-hexyl-7-phenyl-1-tosyl-2,3,4,5,6,9-hexahydro-1H-benzo[b]azepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); caesium carbonate;
In
1,2-dimethoxyethane;
at 85 ℃;
Overall yield = 74 %;
DOI:10.1002/chem.201501710
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron tribromide / dichloromethane / 4.5 h / -78 - 20 °C
1.2: 1 h / 20 °C
2.1: potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate / toluene / 16 h / 70 °C
3.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane / 85 °C
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; boron tribromide; caesium carbonate;
In
1,2-dimethoxyethane; dichloromethane; toluene;
3.1: |Suzuki-Miyaura Coupling;
DOI:10.1002/chem.201501710
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C
2: trifluoroacetic acid / dichloromethane / 12 h / 0 - 20 °C
3: potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate / toluene / 16 h / 70 °C
4: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane / 85 °C
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; di-isopropyl azodicarboxylate; caesium carbonate; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; toluene;
1: |Mitsunobu Displacement / 4: |Suzuki-Miyaura Coupling;
DOI:10.1002/chem.201501710