(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: (1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester
• CAS No.: 923274-72-0
• Molecular Formula: C₃₅H₄₁N₃O₇
• Molecular Weight: 615.726

Synonyms:

Chemical Property of (1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of (1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester

There total 1 articles about (1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2R,4S)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-cyclopenteanecarboxylic acid tert-butyl ester (862174-62-7) + 7-Methoxy-8-methyl-2-phenylquinazolin-4-ol (922520-29-4) → (1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester (923274-72-0)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.05.029

Reference yield:

(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester (923274-72-0) → (1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid (923274-73-1)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2010.05.029

upstream raw materials:

(1R,2R,4S)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-cyclopenteanecarboxylic acid tert-butyl ester

7-Methoxy-8-methyl-2-phenylquinazolin-4-ol

Downstream raw materials:

(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

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