(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

Base Information

Chemical Name:(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid
CAS No.:923274-73-1
Molecular Formula:C₃₁H₃₃N₃O₇
Molecular Weight:559.619
Hs Code.:

(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

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Chemical Property of (1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

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Technology Process of (1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

There total 2 articles about (1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 923274-73-1
(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:

Reference yield:

: 923274-72-0
(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinylcyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester

: 923274-73-1
(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2010.05.029

Reference yield:

: 923274-73-1
(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-8-methyl-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

: 55863-02-0
N-methylhex-5-en-1-amine

: 923274-74-2
(1R,2S)-1-((1R,2R,4R)-2-(hex-5-enyl(methyl)carbamoyl)-4-(7-methoxy-8-methyl-2-phenylquinazolin-4-yloxy)cyclopentanecarboxamido)-2-vinylcyclopropanecarboxylic acid ethyl ester

Guidance literature:: With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2010.05.029