methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Base Information

Chemical Name:methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate
CAS No.:1584732-01-3
Molecular Formula:C₃₄H₃₈Cl₂N₂O₄S
Molecular Weight:641.659
Hs Code.:

methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Synonyms:

Suppliers and Price of methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

There total 4 articles about methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131803-48-0
methyl 6-bromomethylnicotinate

: 1584732-01-3
methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 0.25 h / -78 °C / Inert atmosphere

1.3: 1 h / -78 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3.1: cyanomethylenetributyl-phosphorane / toluene / 12 h / Inert atmosphere

With tetrabutyl ammonium fluoride; cyanomethylenetributyl-phosphorane; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1021/jm401911v

Reference yield:

: 1584731-99-6
methyl 6-(((2R,5R,6R)-4-((S)-2-((tert-butyldimethylsilyl)oxy)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

: 1584732-01-3
methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

2: cyanomethylenetributyl-phosphorane / toluene / 12 h / Inert atmosphere

With tetrabutyl ammonium fluoride; cyanomethylenetributyl-phosphorane; In tetrahydrofuran; toluene;
DOI:10.1021/jm401911v

Reference yield:

: 5470-70-2
Methyl 6-methylnicotinate

: 1584732-01-3
methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / 75 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.25 h / -78 °C / Inert atmosphere

2.3: 1 h / -78 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4.1: cyanomethylenetributyl-phosphorane / toluene / 12 h / Inert atmosphere

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; cyanomethylenetributyl-phosphorane; lithium hexamethyldisilazane; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; toluene;
DOI:10.1021/jm401911v