methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Base Information

Chemical Name:methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate
CAS No.:1584732-02-4
Molecular Formula:C₃₄H₃₈Cl₂N₂O₆S
Molecular Weight:673.658
Hs Code.:

methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

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Chemical Property of methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

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Technology Process of methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

There total 6 articles about methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1584732-01-3
methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

: 1584732-02-4
methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1021/jm401911v

Reference yield:

: 131803-48-0
methyl 6-bromomethylnicotinate

: 1584732-02-4
methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 0.25 h / -78 °C / Inert atmosphere

1.3: 1 h / -78 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3.1: cyanomethylenetributyl-phosphorane / toluene / 12 h / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; cyanomethylenetributyl-phosphorane; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm401911v

Reference yield:

: 5470-70-2
Methyl 6-methylnicotinate

: 1584732-02-4
methyl 6-(((2R,5R,6R)-4-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl)methyl)nicotinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / 75 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.25 h / -78 °C / Inert atmosphere

2.3: 1 h / -78 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4.1: cyanomethylenetributyl-phosphorane / toluene / 12 h / Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C / Inert atmosphere

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; cyanomethylenetributyl-phosphorane; lithium hexamethyldisilazane; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/jm401911v