3-{5-[(E)-(3-chloro-2-hydroxyphenyl)diazenyl]-4-methyl-6-oxo-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl}-2-(chloromethyl)quinazolin-4(3H)-one

Base Information

Chemical Name:3-{5-[(E)-(3-chloro-2-hydroxyphenyl)diazenyl]-4-methyl-6-oxo-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl}-2-(chloromethyl)quinazolin-4(3H)-one
CAS No.:1319147-82-4
Molecular Formula:C₂₀H₁₄Cl₂N₆O₃S
Molecular Weight:489.342
Hs Code.:

3-{5-[(E)-(3-chloro-2-hydroxyphenyl)diazenyl]-4-methyl-6-oxo-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl}-2-(chloromethyl)quinazolin-4(3H)-one

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Chemical Property of 3-{5-[(E)-(3-chloro-2-hydroxyphenyl)diazenyl]-4-methyl-6-oxo-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl}-2-(chloromethyl)quinazolin-4(3H)-one

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Technology Process of 3-{5-[(E)-(3-chloro-2-hydroxyphenyl)diazenyl]-4-methyl-6-oxo-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl}-2-(chloromethyl)quinazolin-4(3H)-one

There total 5 articles about 3-{5-[(E)-(3-chloro-2-hydroxyphenyl)diazenyl]-4-methyl-6-oxo-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl}-2-(chloromethyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1319147-98-2
C₁₁H₁₀ClN₅O₂S

: 98592-35-9
2-(chloromethyl)-4H-benzo[d][1,3]oxazin-4-one

: 1319147-82-4
3-{5-[(E)-(3-chloro-2-hydroxyphenyl)diazenyl]-4-methyl-6-oxo-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl}-2-(chloromethyl)quinazolin-4(3H)-one

Guidance literature:: In pyridine; for 9h; Reflux;
DOI:10.1016/j.bmcl.2011.05.031

Reference yield:

: 38191-33-2
2-amino-6-chlorophenol

: 1319147-82-4
3-{5-[(E)-(3-chloro-2-hydroxyphenyl)diazenyl]-4-methyl-6-oxo-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl}-2-(chloromethyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C

1.2: 5 °C

2.1: sodium ethanolate / 20 °C

3.1: pyridine / 9 h / Reflux

With hydrogenchloride; sodium ethanolate; sodium nitrite; In pyridine; water;
DOI:10.1016/j.bmcl.2011.05.031

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1319147-82-4
3-{5-[(E)-(3-chloro-2-hydroxyphenyl)diazenyl]-4-methyl-6-oxo-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl}-2-(chloromethyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: benzene / 2 h / Reflux

2: sulfuric acid / ethanol; acetic acid / 0.25 h / 100 °C

3: pyridine / 9 h / Reflux

With sulfuric acid; In pyridine; ethanol; acetic acid; benzene;
DOI:10.1016/j.bmcl.2011.05.031