38191-33-2

Basic information

• Product Name: 2-AMINO-6-CHLORO-PHENOL
• Synonyms: phenol, 2-amino-6-chloro-;2-chloro-6-aMinophenole;3-Chloro-2-hydroxyaniline;2-AMino-6-chlorphenol
• CAS NO: 38191-33-2
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• Mol File: 38191-33-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 80-81℃
• Boiling Point: 247℃
• Flash Point: 103℃
• Appearance: /
• Density: 1.406
• Vapor Pressure: 0.0163mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.28±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-6-CHLORO-PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-CHLORO-PHENOL(38191-33-2)
• EPA Substance Registry System: 2-AMINO-6-CHLORO-PHENOL(38191-33-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 38191-33-2(Hazardous Substances Data)

Usage

General Description

2-Amino-6-chloro-phenol is an organic compound with the chemical formula C6H6ClNO. It is a derivative of phenol and contains both amino and chloro functional groups. 2-AMINO-6-CHLORO-PHENOL is commonly used in the production of hair dyes and pharmaceuticals. Its presence in hair dyes can cause allergic reactions in some individuals, and it is important to be cautious when using products that contain this chemical. Additionally, 2-amino-6-chloro-phenol has been studied for its potential anti-cancer properties and has shown promise as a therapeutic agent. However, further research is needed to fully understand its mechanisms of action and potential applications in medicine.

InChI:InChI=1/C6H6ClNO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H,8H2

Upstream product

• 95-57-8 2-monochlorophenol 
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Downstream Products

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• 84326-06-7 [4-(8-Chloro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-acetic acid methyl ester 
• 84326-12-5 2-[4-(8-Chloro-2-oxo-2H-benzo[1,4]oxazin-3-yl)-phenyl]-propionic acid methyl ester 
• 156661-93-7 2--6-chloro-O-(methylsulfonyl)phenol 
• 121996-73-4 diethyl N-(3-chloro-2-hydroxyphenyl)aminomethylenemalonate 
• 133296-68-1 6-Chlor-phenol-<2-azo-1>-naphthol-(2) 
• 315228-20-7 7-chloro-2-(2-fluoro-4-nitro-benzyl)-benzoxazole 
• 156661-95-9 2-chloro-6-<(methylsulfonyl)amino>phenol 
• 156661-88-0 Phosphoric acid 2-chloro-6-methanesulfonylamino-phenyl ester diethyl ester 

Relevant articles and documents

Direct Hydrogenation of Nitroaromatics at Room Temperature Catalyzed by Magnetically Recoverable Cu@Fe2O3 Nanoparticles

Metal embedded in metal oxide nanoparticles are active as catalyst in plethora of industrially important reactions. Herein, embedded Cu@Fe2O3 nanoparticles was synthesized via a one step hydrothermal strategy which selectively catalyzes the hydrogenation of diverse nitroaromatics in H2O at room temperature. The remarkable catalytic performance is due to the successful hybridization of metallic Cu and Fe2O3 which in turn allows easy electroflipping between various oxidation states of Cu and Fe. Azo- and azoxy-compounds are not formed during the catalyzed process. This evidently establish that the hydrogenation of nitroaromatics proceeds via direct route with >99percent selectivity to the corresponding anilines.

Fe-Catalyzed Amination of (Hetero)Arenes with a Redox-Active Aminating Reagent under Mild Conditions

A novel and efficient Fe-catalyzed direct C?H amination (NH2) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds. Mechanistic studies demonstrate that a radical pathway could be involved in this transformation.

2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site

2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.