C₂₄H₂₂ClF₃N₂O₃

Base Information

Chemical Name:C₂₄H₂₂ClF₃N₂O₃
CAS No.:1334393-00-8
Molecular Formula:C₂₄H₂₂ClF₃N₂O₃
Molecular Weight:478.898
Hs Code.:

C<sub>24</sub>H<sub>22</sub>ClF<sub>3</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:

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Chemical Property of C₂₄H₂₂ClF₃N₂O₃

Chemical Property:

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Technology Process of C₂₄H₂₂ClF₃N₂O₃

There total 12 articles about C₂₄H₂₂ClF₃N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873203-36-2
1-bromo-4-[4-(trifluoromethoxy)phenoxy]benzene

: 1334393-00-8
C₂₄H₂₂ClF₃N₂O₃

Guidance literature:: Multi-step reaction with 7 steps

1: n-butyllithium / tetrahydrofuran / -78 °C

2: hydrogenchloride / water / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

4: ammonia / ethanol; water / 140 °C

5: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C

6: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

7: sodium tris(acetoxy)borohydride; acetic acid / DCE / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; trichloroisocyanuric acid; ammonia; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; DCE; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

: 958457-25-5
3-benzyloxy-6-methyl-2-(O-tert-butyldimethylsily l)-hydroxymethyl-pyran-4(1H)-one

: 1334393-00-8
C₂₄H₂₂ClF₃N₂O₃

Guidance literature:: Multi-step reaction with 7 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

4: ammonia / ethanol; water / 140 °C

5: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C

6: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

7: sodium tris(acetoxy)borohydride; acetic acid / DCE / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; trichloroisocyanuric acid; palladium 10% on activated carbon; ammonia; hydrogen; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium carbonate; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; In methanol; DCE; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

: GSK₉₃₂₁₂₁

: 1334393-00-8
C₂₄H₂₂ClF₃N₂O₃

Guidance literature:: Multi-step reaction with 2 steps

1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / DCE / 20 °C

With sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; acetic acid; dimethyl sulfoxide; triethylamine; In DCE; dichloromethane;
DOI:10.1016/j.bmcl.2011.07.044