4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid

Base Information

Chemical Name:4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid
CAS No.:1308379-70-5
Molecular Formula:C₃₆H₃₈F₄N₆O₇
Molecular Weight:742.727
Hs Code.:

4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid

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Chemical Property of 4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid

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Technology Process of 4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid

There total 9 articles about 4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₅H₅₄F₄N₆O₉

: 1308379-70-5
4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/acs.jmedchem.6b01071

Reference yield:

: 1308380-36-0
methanesulfonic acid (R)-2-tert-butoxycarbonylamino-2-2-methoxy-phenyl-ethyl ester

: 1308379-70-5
4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere

2.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere

2.2: 0.33 h / 20 °C / Inert atmosphere

3.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C

5.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b01071

Reference yield:

: 1308380-37-1
[(R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-1-(2-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

: 1308379-70-5
4-[2-((R)-1-amino-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl)-phenoxy]-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trihalide / dichloromethane; 1,2-dichloro-ethane / 48 h / -78 - 40 °C / Inert atmosphere

1.2: 0.33 h / 20 °C / Inert atmosphere

2.1: triethylamine / 1,2-dichloro-ethane / 3 h / 40 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.6b01071