1-(2-Methoxy-1-methyl-cyclopent-2-enyl)-4-methyl-cyclohex-3-enecarboxylic acid

Base Information

• Chemical Name: 1-(2-Methoxy-1-methyl-cyclopent-2-enyl)-4-methyl-cyclohex-3-enecarboxylic acid
• CAS No.: 100231-45-6
• Molecular Formula: C₁₅H₂₂O₃
• Molecular Weight: 250.338
• Mol file: 100231-45-6.mol

Synonyms:

Chemical Property of 1-(2-Methoxy-1-methyl-cyclopent-2-enyl)-4-methyl-cyclohex-3-enecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-Methoxy-1-methyl-cyclopent-2-enyl)-4-methyl-cyclohex-3-enecarboxylic acid

There total 5 articles about 1-(2-Methoxy-1-methyl-cyclopent-2-enyl)-4-methyl-cyclohex-3-enecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C21H36O3Si (100231-43-4,100231-44-5) → 1-(2-Methoxy-1-methyl-cyclopent-2-enyl)-4-methyl-cyclohex-3-enecarboxylic acid (100231-45-6,100231-46-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 6h;

DOI:10.1021/jo00354a018

Reference yield:

4-methylcyclohex-3-enecarboxylic acid (4342-60-3) → 1-(2-Methoxy-1-methyl-cyclopent-2-enyl)-4-methyl-cyclohex-3-enecarboxylic acid (100231-45-6,100231-46-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / DMAP, DCC / CH₂Cl₂ / 5 h / Ambient temperature

3: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 6 h

With dmap; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00354a018

Reference yield:

2-hydroxy-3-methylcyclopent-2-en-1-one (80-71-7) → 1-(2-Methoxy-1-methyl-cyclopent-2-enyl)-4-methyl-cyclohex-3-enecarboxylic acid (100231-45-6,100231-46-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 8.11 g / DIBAL / diethyl ether; hexane / 4 h / 0 °C

2: 96 percent / DMAP, DCC / CH₂Cl₂ / 5 h / Ambient temperature

4: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 6 h

With dmap; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;

DOI:10.1021/jo00354a018

upstream raw materials:

C₂₁H₃₆O₃Si

4-methylcyclohex-3-enecarboxylic acid

2-hydroxy-3-methylcyclopent-2-en-1-one

3-methyl-2-methoxycyclopent-2-en-1-ol

Downstream raw materials:

Methanesulfonic acid 1-(2-methoxy-1-methyl-cyclopent-2-enyl)-4-methyl-cyclohex-3-enylmethyl ester

1-(2-Methoxy-1-methyl-cyclopent-2-enyl)-4-methyl-cyclohex-3-enecarboxylic acid methyl ester

Refernces