3-( (1r,4R)-N-( (1r,4R)-4-(6-hydroxypyridazin-3-yloxy)cyclohexyl )-4-methylcyclohexanecarboxamido)-5-(4,4,4-tri f luoro-3,3-dimethylbut-1-ynyl ) thiophene-2-carboxyl ic acid

Base Information

Chemical Name:3-( (1r,4R)-N-( (1r,4R)-4-(6-hydroxypyridazin-3-yloxy)cyclohexyl )-4-methylcyclohexanecarboxamido)-5-(4,4,4-tri f luoro-3,3-dimethylbut-1-ynyl ) thiophene-2-carboxyl ic acid
CAS No.:1263101-93-4
Molecular Formula:C₂₉H₃₄F₃N₃O₅S
Molecular Weight:593.667
Hs Code.:

3-( (1r,4R)-N-( (1r,4R)-4-(6-hydroxypyridazin-3-yloxy)cyclohexyl )-4-methylcyclohexanecarboxamido)-5-(4,4,4-tri f luoro-3,3-dimethylbut-1-ynyl ) thiophene-2-carboxyl ic acid

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Chemical Property of 3-( (1r,4R)-N-( (1r,4R)-4-(6-hydroxypyridazin-3-yloxy)cyclohexyl )-4-methylcyclohexanecarboxamido)-5-(4,4,4-tri f luoro-3,3-dimethylbut-1-ynyl ) thiophene-2-carboxyl ic acid

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Technology Process of 3-( (1r,4R)-N-( (1r,4R)-4-(6-hydroxypyridazin-3-yloxy)cyclohexyl )-4-methylcyclohexanecarboxamido)-5-(4,4,4-tri f luoro-3,3-dimethylbut-1-ynyl ) thiophene-2-carboxyl ic acid

There total 2 articles about 3-( (1r,4R)-N-( (1r,4R)-4-(6-hydroxypyridazin-3-yloxy)cyclohexyl )-4-methylcyclohexanecarboxamido)-5-(4,4,4-tri f luoro-3,3-dimethylbut-1-ynyl ) thiophene-2-carboxyl ic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₆F₃N₃O₅S

: 1263101-93-4
3-( (1r,4R)-N-( (1r,4R)-4-(6-hydroxypyridazin-3-yloxy)cyclohexyl )-4-methylcyclohexanecarboxamido)-5-(4,4,4-tri f luoro-3,3-dimethylbut-1-ynyl ) thiophene-2-carboxyl ic acid

Guidance literature:: With sodium acetate; acetic acid; at 100 ℃;
DOI:10.1021/jm401420j

Reference yield:

: 1263101-87-6
methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate

: 1263101-93-4
3-( (1r,4R)-N-( (1r,4R)-4-(6-hydroxypyridazin-3-yloxy)cyclohexyl )-4-methylcyclohexanecarboxamido)-5-(4,4,4-tri f luoro-3,3-dimethylbut-1-ynyl ) thiophene-2-carboxyl ic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.17 h / 20 °C

1.2: 1 h / 80 °C / Microwave irradiation

2.1: acetic acid; sodium acetate / 100 °C

With potassium tert-butylate; sodium acetate; acetic acid; In dimethyl sulfoxide;
DOI:10.1021/jm401420j