methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate

Base Information

Chemical Name:methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate
CAS No.:1263101-87-6
Molecular Formula:C₂₇H₃₄F₃NO₄S
Molecular Weight:525.632
Hs Code.:

methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate

Synonyms:methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate

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Chemical Property of methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate

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Technology Process of methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate

There total 1 articles about methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1263101-86-5
methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-(1-(trifluoromethyl)cyclobutanecarbonyl)thiophene-2-carboxylate

: 90965-06-3
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

: 1263101-87-6
methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃;
DOI:10.1021/jm401420j

Reference yield:

: 1263101-87-6
methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate

: 1263101-93-4
3-( (1r,4R)-N-( (1r,4R)-4-(6-hydroxypyridazin-3-yloxy)cyclohexyl )-4-methylcyclohexanecarboxamido)-5-(4,4,4-tri f luoro-3,3-dimethylbut-1-ynyl ) thiophene-2-carboxyl ic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.17 h / 20 °C

1.2: 1 h / 80 °C / Microwave irradiation

2.1: acetic acid; sodium acetate / 100 °C

With potassium tert-butylate; sodium acetate; acetic acid; In dimethyl sulfoxide;
DOI:10.1021/jm401420j

Reference yield:

: 141-30-0
3,6-dichlorpyridazine

: 1263101-87-6
methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate

: C₃₀H₃₆F₃N₃O₅S

Guidance literature:: methyl 3-((1r,4R)-N-((1r,4R)-4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)-5-((1-(trifluoromethyl)cyclobutyl)ethynyl)thiophene-2-carboxylate; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

3,6-dichlorpyridazine; With dimethyl sulfoxide; at 80 ℃; for 1h; Microwave irradiation;
DOI:10.1021/jm401420j