5-[2-(9-{4-[1-(2-fluoro-6-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yloxy]piperidin-4-yl}nonylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

Base Information

Chemical Name:5-[2-(9-{4-[1-(2-fluoro-6-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yloxy]piperidin-4-yl}nonylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one
CAS No.:1333165-88-0
Molecular Formula:C₃₈H₅₀FN₅O₅
Molecular Weight:675.844
Hs Code.:

5-[2-(9-{4-[1-(2-fluoro-6-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yloxy]piperidin-4-yl}nonylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

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Chemical Property of 5-[2-(9-{4-[1-(2-fluoro-6-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yloxy]piperidin-4-yl}nonylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

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Technology Process of 5-[2-(9-{4-[1-(2-fluoro-6-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yloxy]piperidin-4-yl}nonylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

There total 9 articles about 5-[2-(9-{4-[1-(2-fluoro-6-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yloxy]piperidin-4-yl}nonylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333165-86-8
3-fluoro-2-[3-(piperidin-4-yloxy)-4,5,6,7-tetrahydro-1H-indazol-1-yl]phenol

: 1333165-88-0
5-[2-(9-{4-[1-(2-fluoro-6-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yloxy]piperidin-4-yl}nonylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / acetonitrile / 16 h / Reflux; Inert atmosphere

2: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 16 h / Inert atmosphere

3: sodium tris(acetoxy)borohydride / ethanol; dichloromethane / 16 h / Inert atmosphere

4: triethylamine hydrofluoride / tetrahydrofuran / 16 h / Inert atmosphere

With sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm2007535

Reference yield:

: 1333205-38-1
acetic acid N'-(2,6-difluorophenyl)hydrazide

: 1333165-88-0
5-[2-(9-{4-[1-(2-fluoro-6-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yloxy]piperidin-4-yl}nonylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: phosphorus trichloride / acetonitrile / 40 h / 50 °C / Inert atmosphere

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1 h / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 16 h / Reflux; Inert atmosphere

4.2: 2 h / Reflux

5.1: sodium hydrogencarbonate / acetonitrile / 16 h / Reflux; Inert atmosphere

6.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 16 h / Inert atmosphere

7.1: sodium tris(acetoxy)borohydride / ethanol; dichloromethane / 16 h / Inert atmosphere

8.1: triethylamine hydrofluoride / tetrahydrofuran / 16 h / Inert atmosphere

With hydrogenchloride; di-isopropyl azodicarboxylate; potassium tert-butylate; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine hydrofluoride; triethylamine; triphenylphosphine; phosphorus trichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile; 2.1: Mitsunobu reaction;
DOI:10.1021/jm2007535

Reference yield:

: 1333165-87-9
3-fluoro-2-{3-[1-(9-hydroxynonyl)piperidin-4-yloxy]-4,5,6,7-tetrahydro-1H-indazol-1-yl}phenol

: 1333165-88-0
5-[2-(9-{4-[1-(2-fluoro-6-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yloxy]piperidin-4-yl}nonylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 16 h / Inert atmosphere

2: sodium tris(acetoxy)borohydride / ethanol; dichloromethane / 16 h / Inert atmosphere

3: triethylamine hydrofluoride / tetrahydrofuran / 16 h / Inert atmosphere

With sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm2007535