acetic acid N'-(2,6-difluorophenyl)hydrazide

Base Information

Chemical Name:acetic acid N'-(2,6-difluorophenyl)hydrazide
CAS No.:1333205-38-1
Molecular Formula:C₈H₈F₂N₂O
Molecular Weight:186.161
Hs Code.:

Synonyms:

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Chemical Property of acetic acid N'-(2,6-difluorophenyl)hydrazide

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Technology Process of acetic acid N'-(2,6-difluorophenyl)hydrazide

There total 1 articles about acetic acid N'-(2,6-difluorophenyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 119452-66-3
(2,6-difluorophenyl)hydrazine

: 108-24-7
acetic anhydride

: 1333205-38-1
acetic acid N'-(2,6-difluorophenyl)hydrazide

Guidance literature:: In toluene; for 1h; Inert atmosphere;
DOI:10.1021/jm2007535

Reference yield:

: 1333205-38-1
acetic acid N'-(2,6-difluorophenyl)hydrazide

: C₄₄H₆₄FN₅O₅Si

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus trichloride / acetonitrile / 40 h / 50 °C / Inert atmosphere

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1 h / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 16 h / Reflux; Inert atmosphere

4.2: 2 h / Reflux

5.1: sodium hydrogencarbonate / acetonitrile / 16 h / Reflux; Inert atmosphere

6.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 16 h / Inert atmosphere

7.1: sodium tris(acetoxy)borohydride / ethanol; dichloromethane / 16 h / Inert atmosphere

With hydrogenchloride; di-isopropyl azodicarboxylate; potassium tert-butylate; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; triphenylphosphine; phosphorus trichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile; 2.1: Mitsunobu reaction;
DOI:10.1021/jm2007535

Reference yield:

: 1333205-38-1
acetic acid N'-(2,6-difluorophenyl)hydrazide

: 1333165-88-0
5-[2-(9-{4-[1-(2-fluoro-6-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yloxy]piperidin-4-yl}nonylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: phosphorus trichloride / acetonitrile / 40 h / 50 °C / Inert atmosphere

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1 h / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 16 h / Reflux; Inert atmosphere

4.2: 2 h / Reflux

5.1: sodium hydrogencarbonate / acetonitrile / 16 h / Reflux; Inert atmosphere

6.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 16 h / Inert atmosphere

7.1: sodium tris(acetoxy)borohydride / ethanol; dichloromethane / 16 h / Inert atmosphere

8.1: triethylamine hydrofluoride / tetrahydrofuran / 16 h / Inert atmosphere

With hydrogenchloride; di-isopropyl azodicarboxylate; potassium tert-butylate; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine hydrofluoride; triethylamine; triphenylphosphine; phosphorus trichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile; 2.1: Mitsunobu reaction;
DOI:10.1021/jm2007535