(1S,2R,3R)-2-methyl-3-phenyl-1-(1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole-2-sulfonylamino)cyclopropane-1-carboxylic acid hydrochloride

Base Information

• Chemical Name: (1S,2R,3R)-2-methyl-3-phenyl-1-(1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole-2-sulfonylamino)cyclopropane-1-carboxylic acid hydrochloride
• CAS No.: 1288977-38-7
• Molecular Formula: C₂₁H₂₂N₄O₄S*ClH
• Molecular Weight: 462.957

Synonyms:

Chemical Property of (1S,2R,3R)-2-methyl-3-phenyl-1-(1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole-2-sulfonylamino)cyclopropane-1-carboxylic acid hydrochloride

Chemical Property:

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Safty Information:

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Technology Process of (1S,2R,3R)-2-methyl-3-phenyl-1-(1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole-2-sulfonylamino)cyclopropane-1-carboxylic acid hydrochloride

There total 2 articles about (1S,2R,3R)-2-methyl-3-phenyl-1-(1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole-2-sulfonylamino)cyclopropane-1-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H30N4O4S → (1S,2R,3R)-2-methyl-3-phenyl-1-(1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole-2-sulfonylamino)cyclopropane-1-carboxylic acid hydrochloride (1288977-38-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 12h;

DOI:10.1021/jm101609j

Reference yield:

NSC 700996 (4744-53-0) + (1S,2R,3R)-2-methyl-1-(2-oxo-oxazolidine-3-sulfonylamino)-3-phenyl-cyclopropanecarboxylic acid t-butyl ester → (1S,2R,3R)-2-methyl-3-phenyl-1-(1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole-2-sulfonylamino)cyclopropane-1-carboxylic acid hydrochloride (1288977-38-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methyl-morpholine / 1,4-dioxane / 100 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/jm101609j

upstream raw materials:

NSC 700996

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