4744-53-0Relevant academic research and scientific papers
Design, synthesis and biological evaluation of novel molecules as potent PARP-1 inhibitors
Shen, Hui,Ge, Yiran,Wang, Junwei,Li, Hui,Xu, Yungen,Zhu, Qihua
, (2021)
Two series of novel compounds with inhibition activity against PARP-1 were designed and synthesized. All target compounds were evaluated for their PARP-1 inhibition activity, and compounds with high PARP-1 inhibition activity were selected to assess for cellular assays in vitro. Among them, compound II-4 displayed impressive results in both PARP-1 enzyme inhibition with IC50 value of 0.51 nM and anti-proliferation activity against HCT116 and HCC1937 cell lines with IC50 values of 6.62 nM and 12.65 nM, respectively. Also, II-4 exhibited good metabolic stability in vitro with t1/2 of 173.25 min and CLint of 0.04 mL/min/mg. Prediction of molecular properties and protein docking were applied to structure design. Our study provides potential lead compounds and design directions for the development of PARP-1 inhibitors.
SALT INDUCIBLE KINASE INHIBITORS
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Page/Page column 75, (2022/02/15)
The present application provides compounds that modulate the activity of one or more salt inducible kinases (SIKs). Pharmaceutical composition and methods of treating diseases associated with abnormal expression and/or activity of one or more SIKs are also provided.
PARP inhibitors containing phthalazin-1(2H)-one structure, and preparation method and medical application thereof
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, (2019/02/04)
The invention relates to the field of medicinal chemistry, specifically to 4-(4-fluoro-3-(1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazinyl-2-carbonyl)benzyl)phthalazin-1(2H)-one derivatives (I). The formula I is as described in the specification, and R in the formula I is as defined in the specification. The invention also discloses a preparation method for the derivatives, and pharmaceutical compositions containing the derivatives. The results of pharmacodynamic tests prove that the derivatives of the invention have PARP inhibitory activity and can be used as a single therapeutic agent fortumors or be used in combination with other antitumor drugs, so the effects of improving the efficacy of conventional antitumor drugs and reducing the dosage and toxicity of conventional antitumor drugs are obtained.
Benzo[4,5]imidazole[1,2-a]pyrazine ketone derivatives as well as preparation method and application thereof
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, (2019/05/28)
The invention provides benzo[4,5]imidazole[1,2-a]pyrazine ketone derivatives and pharmaceutically acceptable salt, wherein the structure is as shown in a general formula I. The invention also discloses a preparation method of the benzo[4,5]imidazole[1,2-a]pyrazine ketone derivatives as well as the application of the benzo[4,5]imidazole[1,2-a]pyrazine ketone derivatives to the preparation of anti-tumor medicines and the preparation of PARP inhibitor medicines.
Synthesis of 5H-pyrazino[2,3-b]indoles from indole-2,3-dione derivatives
Bergman, Jan,Vallberg, Hans
, p. 742 - 752 (2007/10/03)
Reaction of N-acetylindol-2,3-diones with ethylenediamines gave the dihydropyrazinones 11, which could, after dehydrogenation and deacetylation, be transformed to the corresponding 5H-pyrazino[2,3-e]indoles 5. N,N-Dimethylaminoethylation of the anion of 5
Heterocyclization of the 2-aminoalkyl (and aryl) benzimidazoles under phase transfer catalysis conditions
Cherkaoui, O.,Essassi, E.M.,Zniber, R.
, p. 255 - 259 (2007/10/02)
A number of new imidazolo (pyrazino and diazepino) benzimidazoles have been prepared by reaction between 2-aminoalkyl (and aryl)benzimidazoles and dibromoalkanes Br-(CH2)n-Br under phase transfer catalysis conditions.These products have been characterized by 1H NMR, IR, MS and their microanalysis. --- Key words: heterocyclization / benzimidazole / diazepinobenzimidazole / benzimidazolo benzodiazepin
