C₅₀H₇₇N₃O₁₀

Base Information

• Chemical Name: C₅₀H₇₇N₃O₁₀
• CAS No.: 157800-36-7
• Molecular Formula: C₅₀H₇₇N₃O₁₀
• Molecular Weight: 880.175
• Mol file: 157800-36-7.mol

Synonyms:

Chemical Property of C₅₀H₇₇N₃O₁₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₀H₇₇N₃O₁₀

There total 1 articles about C₅₀H₇₇N₃O₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H29NO4 + C31H50N2O7 → C50H77N3O10 (157800-36-7)

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2007.04.037

Reference yield:

C50H77N3O10 (157800-36-7) → cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl) (157800-20-9)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / 16 h / 0 - 20 °C

2: DCC / 4 h / 0 - 20 °C

3: 39 percent / H₂; 4-pyrrolidino-pyridine / Pd/C / dioxane; ethanol / 10 h / 95 °C

With hydrogenchloride; hydrogen; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol;

DOI:10.1016/j.bmcl.2007.04.037

Reference yield:

C50H77N3O10 (157800-36-7) → cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-cyclohexylalanyl-(R)-2-hydroxy-isovaleroyl)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl / 16 h / 0 - 20 °C

2: DCC / 4 h / 0 - 20 °C

3: 39 percent / H₂; 4-pyrrolidino-pyridine / Pd/C / dioxane; ethanol / 10 h / 95 °C

4: 38 percent / H₂ / PtO₂ / H₂O; acetic acid / 18 h / 50 °C / 3000.3 - 3750.38 Torr

With hydrogenchloride; hydrogen; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; platinum(IV) oxide; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; acetic acid;

DOI:10.1016/j.bmcl.2007.04.037

Downstream raw materials:

C₄₆H₆₉N₃O₁₀

cyclo(N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-isoleucyl-(R)-2-hydroxy-isovaleroyl-N-methyl-(S)-phenylalanyl-(R)-2-hydroxy-isovaleroyl)