2,2-Dimethyl-propionic acid 5-{3-[(S)-2-({6-[(adamantan-1-ylmethyl)-carbamoyl]-1H-benzoimidazole-5-carbonyl}-amino)-3-phenyl-propionylamino]-5-[1-(2,2-dimethyl-propionyloxymethyl)-1H-tetrazol-5-yl]-phenyl}-tetrazol-1-ylmethyl ester

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Chemical Name:2,2-Dimethyl-propionic acid 5-{3-[(S)-2-({6-[(adamantan-1-ylmethyl)-carbamoyl]-1H-benzoimidazole-5-carbonyl}-amino)-3-phenyl-propionylamino]-5-[1-(2,2-dimethyl-propionyloxymethyl)-1H-tetrazol-5-yl]-phenyl}-tetrazol-1-ylmethyl ester
CAS No.:167992-94-1
Molecular Formula:C₄₉H₅₇N₁₃O₇
Molecular Weight:940.074
Hs Code.:

2,2-Dimethyl-propionic acid 5-{3-[(S)-2-({6-[(adamantan-1-ylmethyl)-carbamoyl]-1H-benzoimidazole-5-carbonyl}-amino)-3-phenyl-propionylamino]-5-[1-(2,2-dimethyl-propionyloxymethyl)-1H-tetrazol-5-yl]-phenyl}-tetrazol-1-ylmethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 5-{3-[(S)-2-({6-[(adamantan-1-ylmethyl)-carbamoyl]-1H-benzoimidazole-5-carbonyl}-amino)-3-phenyl-propionylamino]-5-[1-(2,2-dimethyl-propionyloxymethyl)-1H-tetrazol-5-yl]-phenyl}-tetrazol-1-ylmethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid 5-{3-[(S)-2-({6-[(adamantan-1-ylmethyl)-carbamoyl]-1H-benzoimidazole-5-carbonyl}-amino)-3-phenyl-propionylamino]-5-[1-(2,2-dimethyl-propionyloxymethyl)-1H-tetrazol-5-yl]-phenyl}-tetrazol-1-ylmethyl ester

There total 3 articles about 2,2-Dimethyl-propionic acid 5-{3-[(S)-2-({6-[(adamantan-1-ylmethyl)-carbamoyl]-1H-benzoimidazole-5-carbonyl}-amino)-3-phenyl-propionylamino]-5-[1-(2,2-dimethyl-propionyloxymethyl)-1H-tetrazol-5-yl]-phenyl}-tetrazol-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10351-75-4
1H-benzimidazole-5,6-dicarboxylic acid

: 167992-94-1
2,2-Dimethyl-propionic acid 5-{3-[(S)-2-({6-[(adamantan-1-ylmethyl)-carbamoyl]-1H-benzoimidazole-5-carbonyl}-amino)-3-phenyl-propionylamino]-5-[1-(2,2-dimethyl-propionyloxymethyl)-1H-tetrazol-5-yl]-phenyl}-tetrazol-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / 0.33 h / 120 °C

2: acetonitrile / 3.5 h / Heating

3: bromotris(pyrrolidino)phosphonium hexafluorophosphate, diisopropylethylamine / CH₂Cl₂ / 24 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; acetonitrile;
DOI:10.1021/jm9508907

Reference yield:

: 167993-16-0
benzimidazole-5,6-dicarboxylic acid anhydride

: 167992-94-1
2,2-Dimethyl-propionic acid 5-{3-[(S)-2-({6-[(adamantan-1-ylmethyl)-carbamoyl]-1H-benzoimidazole-5-carbonyl}-amino)-3-phenyl-propionylamino]-5-[1-(2,2-dimethyl-propionyloxymethyl)-1H-tetrazol-5-yl]-phenyl}-tetrazol-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 3.5 h / Heating

2: bromotris(pyrrolidino)phosphonium hexafluorophosphate, diisopropylethylamine / CH₂Cl₂ / 24 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; acetonitrile;
DOI:10.1021/jm9508907

Reference yield:

: 17768-41-1
adamantylmethylamine

: 6-((S)-1-{3,5-Bis-[1-(2,2-dimethyl-propionyloxymethyl)-1H-tetrazol-5-yl]-phenylcarbamoyl}-2-phenyl-ethylcarbamoyl)-3H-benzoimidazole-5-carboxylic acid

: 167992-94-1
2,2-Dimethyl-propionic acid 5-{3-[(S)-2-({6-[(adamantan-1-ylmethyl)-carbamoyl]-1H-benzoimidazole-5-carbonyl}-amino)-3-phenyl-propionylamino]-5-[1-(2,2-dimethyl-propionyloxymethyl)-1H-tetrazol-5-yl]-phenyl}-tetrazol-1-ylmethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1021/jm9508907