C₁₃H₁₂F₃N₃O

Base Information

Chemical Name:C₁₃H₁₂F₃N₃O
CAS No.:1404115-77-0
Molecular Formula:C₁₃H₁₂F₃N₃O
Molecular Weight:283.253
Hs Code.:

C<sub>13</sub>H<sub>12</sub>F<sub>3</sub>N<sub>3</sub>O

Synonyms:

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Chemical Property of C₁₃H₁₂F₃N₃O

Chemical Property:

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Technology Process of C₁₃H₁₂F₃N₃O

There total 2 articles about C₁₃H₁₂F₃N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 450412-29-0
1-bromo-3-fluoro-2-iodo-benzene

: 1404115-77-0
C₁₃H₁₂F₃N₃O

Guidance literature:: Multi-step reaction with 7 steps

1: Cu bronze / dimethyl sulfoxide / Heating

2: ammonia / methanol

3: borane-THF / tetrahydrofuran

4: sodium hydroxide / tetrahydrofuran; water

5: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / Heating

6: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol / Heating

7: trifluoroacetic acid / dichloromethane

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; borane-THF; ammonia; potassium acetate; potassium carbonate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; 5: |Suzuki Coupling / 6: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.08.031

Reference yield:

: 1404115-51-0
C₁₀H₈BrF₃O₂

: 1404115-77-0
C₁₃H₁₂F₃N₃O

Guidance literature:: Multi-step reaction with 6 steps

1: ammonia / methanol

2: borane-THF / tetrahydrofuran

3: sodium hydroxide / tetrahydrofuran; water

4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / Heating

5: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol / Heating

6: trifluoroacetic acid / dichloromethane

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; borane-THF; ammonia; potassium acetate; potassium carbonate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol; 4: |Suzuki Coupling / 5: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.08.031

Reference yield:

: 1072855-75-4
6-((2,2,2-trifluoroethoxy)methyl)nicotinic acid

: 1404115-77-0
C₁₃H₁₂F₃N₃O

: C₂₂H₁₈F₆N₄O₃

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.08.031