C₂₆H₂₉F₂N₅O₄S

Base Information

• Chemical Name: C₂₆H₂₉F₂N₅O₄S
• CAS No.: 1062072-52-9
• Molecular Formula: C₂₆H₂₉F₂N₅O₄S
• Molecular Weight: 545.61
• Mol file: 1062072-52-9.mol

Synonyms:

Chemical Property of C₂₆H₂₉F₂N₅O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₉F₂N₅O₄S

There total 7 articles about C₂₆H₂₉F₂N₅O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H23ClF2N4O4S (1062059-88-4) + nitrobenzene (98-95-3,26969-40-4) → C26H29F2N5O4S (1062091-51-3) + C26H29F2N5O4S (1062072-52-9)

Guidance literature:

C₂₀H₂₃ClF₂N₄O₄S; nitrobenzene; With potassium tert-butylate; In dimethyl sulfoxide; at 0 - 20 ℃;

With platinum(IV) oxide; hydrogen; In methanol; dimethyl sulfoxide; ethyl acetate; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2012.06.091

Reference yield:

C19H22F2N4O2 (1269400-88-5) → C26H29F2N5O4S (1062091-51-3) + C26H29F2N5O4S (1062072-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane

2.1: potassium tert-butylate / dimethyl sulfoxide / 0 - 20 °C

2.2: 2 h / 20 °C

With potassium tert-butylate; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2012.06.091

Reference yield:

(3,5-difluorophenyl)hydrazine hydrochloride (502496-27-7) → C26H29F2N5O4S (1062091-51-3) + C26H29F2N5O4S (1062072-52-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydroxide / 100 °C

2.1: triethylamine / ethanol / Heating

3.1: sodium hexamethyldisilazane / Heating

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane

5.1: triethylamine / dichloromethane

6.1: potassium tert-butylate / dimethyl sulfoxide / 0 - 20 °C

6.2: 2 h / 20 °C

With hydrogenchloride; potassium tert-butylate; sodium hexamethyldisilazane; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2012.06.091

upstream raw materials:

(3,5-difluorophenyl)hydrazine hydrochloride

C₁₉H₂₂F₂N₄O₂

C₁₀H₄Cl₂F₂N₂O

C₁₉H₂₁ClF₂N₄O₃

Refernces