(S)-4-{(R)-2-Benzylsulfanyl-1-[((R)-ethoxycarbonyl-phenyl-methyl)-carbamoyl]-ethylcarbamoyl}-2-tert-butoxycarbonylamino-butyric acid octadecyl ester

Base Information

Chemical Name:(S)-4-{(R)-2-Benzylsulfanyl-1-[((R)-ethoxycarbonyl-phenyl-methyl)-carbamoyl]-ethylcarbamoyl}-2-tert-butoxycarbonylamino-butyric acid octadecyl ester
CAS No.:247233-71-2
Molecular Formula:C₄₈H₇₅N₃O₈S
Molecular Weight:854.205
Hs Code.:

(S)-4-{(R)-2-Benzylsulfanyl-1-[((R)-ethoxycarbonyl-phenyl-methyl)-carbamoyl]-ethylcarbamoyl}-2-tert-butoxycarbonylamino-butyric acid octadecyl ester

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Chemical Property of (S)-4-{(R)-2-Benzylsulfanyl-1-[((R)-ethoxycarbonyl-phenyl-methyl)-carbamoyl]-ethylcarbamoyl}-2-tert-butoxycarbonylamino-butyric acid octadecyl ester

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Technology Process of (S)-4-{(R)-2-Benzylsulfanyl-1-[((R)-ethoxycarbonyl-phenyl-methyl)-carbamoyl]-ethylcarbamoyl}-2-tert-butoxycarbonylamino-butyric acid octadecyl ester

There total 8 articles about (S)-4-{(R)-2-Benzylsulfanyl-1-[((R)-ethoxycarbonyl-phenyl-methyl)-carbamoyl]-ethylcarbamoyl}-2-tert-butoxycarbonylamino-butyric acid octadecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Cys(Bzl)-D-Phg-OEt hydrochloride

: 2-tert-butoxycarbonylamino-pentanedioic acid 1-octadecyl ester

: 247233-71-2
(S)-4-{(R)-2-Benzylsulfanyl-1-[((R)-ethoxycarbonyl-phenyl-methyl)-carbamoyl]-ethylcarbamoyl}-2-tert-butoxycarbonylamino-butyric acid octadecyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1124/jpet.103.052696

Reference yield:

: 5068-28-0
(2R)-3-benzylsulfanyl-2-tert-butoxycarbonylamino-propionic acid

: 247233-71-2
(S)-4-{(R)-2-Benzylsulfanyl-1-[((R)-ethoxycarbonyl-phenyl-methyl)-carbamoyl]-ethylcarbamoyl}-2-tert-butoxycarbonylamino-butyric acid octadecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxybenzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 1.33 h / 20 °C

2: hydrochloric acid / dioxane

3: 3-hydroxybenzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1124/jpet.103.052696

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 247233-71-2
(S)-4-{(R)-2-Benzylsulfanyl-1-[((R)-ethoxycarbonyl-phenyl-methyl)-carbamoyl]-ethylcarbamoyl}-2-tert-butoxycarbonylamino-butyric acid octadecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / dimethylformamide / 20 °C

2: H₂; Pd/C / dioxane / 20 °C

3: 3-hydroxybenzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

With 4-methyl-morpholine; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1124/jpet.103.052696