5-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine

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Chemical Name:5-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine
CAS No.:122253-83-2
Molecular Formula:C₄₃H₄₆F₂N₂O₃Si
Molecular Weight:704.932
Hs Code.:

5-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine

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Chemical Property of 5-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine

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Technology Process of 5-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine

There total 6 articles about 5-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122253-41-2
5-Bromomethyl-2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine

: 122253-83-2,123930-31-4
5-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 5 h / Heating

2: 1.) 1.6 M n-BuLi / 1.) THF, hexane, 0.5 h, 2.) 1 h

With n-butyllithium; In toluene;
DOI:10.1021/jm00163a010

Reference yield:

: 123837-56-9
2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester

: 122253-83-2,123930-31-4
5-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / toluene / 3 h / 50 °C

2: LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

3: PBr₃ / toluene; CH₂Cl₂ / 1 h / Ambient temperature

4: toluene / 5 h / Heating

5: 1.) 1.6 M n-BuLi / 1.) THF, hexane, 0.5 h, 2.) 1 h

With lithium aluminium tetrahydride; n-butyllithium; phosphorus tribromide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00163a010

Reference yield:

: 456-14-4
4-fluorobenzamidine hydrochloride

: 122253-83-2,123930-31-4
5-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: KOAc / toluene / 24 h / Heating

2: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / toluene / 3 h / 50 °C

3: LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

4: PBr₃ / toluene; CH₂Cl₂ / 1 h / Ambient temperature

5: toluene / 5 h / Heating

6: 1.) 1.6 M n-BuLi / 1.) THF, hexane, 0.5 h, 2.) 1 h

With lithium aluminium tetrahydride; n-butyllithium; potassium acetate; phosphorus tribromide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00163a010