(1-{(R)-1-{3-[(E)-2-(5-Butyl-pyridin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid methyl ester

Base Information

• Chemical Name: (1-{(R)-1-{3-[(E)-2-(5-Butyl-pyridin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid methyl ester
• CAS No.: 205313-17-3
• Molecular Formula: C₃₆H₄₅NO₃S
• Molecular Weight: 571.824

Synonyms:

Chemical Property of (1-{(R)-1-{3-[(E)-2-(5-Butyl-pyridin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-{(R)-1-{3-[(E)-2-(5-Butyl-pyridin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid methyl ester

There total 3 articles about (1-{(R)-1-{3-[(E)-2-(5-Butyl-pyridin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 1-(((1 (R)-(3-formylphenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetate (153494-26-9) + (5-Butyl-pyridin-2-ylmethyl)-triphenyl-phosphonium; chloride → (1-{(R)-1-{3-[(E)-2-(5-Butyl-pyridin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid methyl ester (205313-17-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/S0960-894X(98)00051-1

Reference yield:

5-butyl-2-methylpyridine (702-16-9) → (1-{(R)-1-{3-[(E)-2-(5-Butyl-pyridin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid methyl ester (205313-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃, Et₃N / CH₂Cl₂

2: acetonitrile / Heating

3: n-BuLi / tetrahydrofuran / 0 - 20 °C

With n-butyllithium; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/S0960-894X(98)00051-1

Reference yield:

5-butyl-2-chloromethyl-pyridine (39256-44-5) → (1-{(R)-1-{3-[(E)-2-(5-Butyl-pyridin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid methyl ester (205313-17-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / Heating

2: n-BuLi / tetrahydrofuran / 0 - 20 °C

With n-butyllithium; In tetrahydrofuran; acetonitrile;

DOI:10.1016/S0960-894X(98)00051-1

upstream raw materials:

Methyl 1-(((1 (R)-(3-formylphenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetate

5-butyl-2-methylpyridine

5-butyl-2-chloromethyl-pyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 205313-17-3 (1-{(R)-1-{3-[(E)-2-(5-Butyl-pyridin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send